2016 Fiscal Year Final Research Report
Molecular mechanism of the development of thymic epithelial cells
| Project/Area Number |
15K19130
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHIGASHI Izumi 徳島大学, 先端酵素学研究所(プロテオ), 准教授 (00596588)
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| Research Collaborator |
TAKAHAMA Yousuke
SAKATA Mie
UDDIN Myn
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 胸腺 / 獲得免疫 / 胸腺上皮細胞 |
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| Outline of Final Research Achievements |
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T cell production in the thymus
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| Free Research Field |
免疫学
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