Exploration of lymphatic vessel regeneration mechanism by artificial lymph node transfer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Chiba University
• Principal Investigator: Shinsuke Akita 千葉大学, 医学部附属病院, 助教 (00436403)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リンパ浮腫 / リンパ節移植 / リンパ管新生

Outline of Final Research Achievements

No lymphangiogenesis and newly developed lymphatic flow into the artificial lymph node were observed. The cause of this result was thought to be a scar formation before newly developed blood circulation was established. A pedicled vascularized lymph node transfer model was developed using abdominal lymphedema model mice. Lymphangiogenesis and afferent lymphatic flow into the transferred lymph node was investigated using this model mice. Newly developed lymphatic flow was observed in some cases and was not observed in others, despite adequate blood flow was confirmed. For establishing afferent lymphatic flow into the transferring lymph node, it seemed to be very important to avoid forming a scar around the transferring lymph node.

Free Research Field

形成外科