2005 Fiscal Year Final Research Report Summary
Research of the role of growth hormone in adult
| Project/Area Number |
16390270
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
CHIHARA Kazuo Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00107955)
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| Co-Investigator(Kenkyū-buntansha) |
OKIMURA Yasuhiko Kobe University, Graduate School of Medicine, Associate Professor, 医学部, 助教授 (30204100)
TAKAHASHI Yutaka Kobe University, Graduate School of Medicine, Lecturer, 医学部附属病院, 講師 (70301281)
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| Project Period (FY) |
2004 – 2005
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| Keywords | growth hormone / adult growth hormone deficiency / metabolic syndrome / gene expression profile / cDNA microarray |
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| Research Abstract |
It is well known that increased visceral fat, decreased lean body mass, decreased total body water, reduced quality of life, sense of vitality, reduced bone mineral density, abnormal lipid profile and increased risk of cardiovascular disease are commonly seen in adult growth hormone deficiency (AGHD). In this study, we have attempted to clarify the significance of GH in metabolic syndrome and ageing by approaching the analysis of pathophysiology in AGHD using an animal model. We found GH deficient rat, known as spontaneous dwarf rat (SDR) demonstrated that visceral obesity and fatty liver, suggesting a good animal model for AGHD. Next we have analyzed gene expression profiles in various tissues in SDR using cDNA microarray. In the heart, we found that GH regulates essential molecules which regulate structural, contractile, remodeling and regenerative functions. Also, in the liver, GH regulated many metabolic regulating enzymes which explained fatty liver change in AGHD (manuscript in preparation). We cloned a novel chemokine as a GH-induced gene in Hepatocyes and the chemokine enhanced insulin-induced glucose uptake in adiopocyte (submitted). We further are investigating the molecular mechanisms of AGHD using these animal model.
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[Journal Article] The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.2005
Author(s)
Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A, Chihara K, Roeder RG, Matsui T
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Journal Title
Genes Cells 10
Pages: 1127-1137
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.2005
Author(s)
Murata M, Miura Y, Hashiramoto A, Kitamura H, Kawasaki H, Shiozawa K, Yoshiya S, Baba H, Chihara K, Shiozawa S
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Journal Title
Int J Mol Med 15
Pages: 649-653
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.2004
Author(s)
Takeno R, Okimura Y, Iguchi G, Kishimoto M, Kudo T, Takahashi K, Takahashi Y, Kaji H, Ohno M, Ikuta H, Kuroda Y, Obara T, Hosoda H, Kangawa K, Chihara K
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Journal Title
Eur J Endocrinol 151
Pages: 447-450
Description
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[Journal Article] Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion.2004
Author(s)
Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K
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Journal Title
Cancer Res 64
Pages: 2222-2228
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Long-term improvement of puality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H).2004
Author(s)
Rosilio M, Blum WF, Edwards DJ, Shavrikova EP, Valle D, Lamberts SW, Erfurth EM, Webb SM, Ross RJ, Chihara K, Henrich G, Herschbach P, Attanasio AF
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Journal Title
J Clin Endocrinol Metab 89
Pages: 1684-1693
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of casein kinase lepsilon in cytokine-induced granulocytic differentiation.2004
Author(s)
Okamura A, Iwata N, Nagata A, Tamekane A, Shimoyama M, Gomyo H, Yakushijin K, Urahama N, Hamaguchi M, Fukui C, Chihara K, Ito M, Matsui T
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Journal Title
Blood 103
Pages: 2997-3004
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A novel splice site mutation of the thiazide-sensitive NaCl cotransporter gene in a Jananese patient with Gitelman syndrome.2004
Author(s)
Iida K, Hanafusa M, Maekawa I, Kudo T, Takahashi K, Yoshioka S, Kishimoto M, Iguchi G, Tsukamoto T, Okimura Y, Kaji H, Chihara K
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Journal Title
Clin Nephrol 62
Pages: 180-184
Description
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