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2005 Fiscal Year Final Research Report Summary

Logistic strategy for molecule-targeting therapy in brain tumors

Research Project

Project/Area Number 16390416
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MINEURA Katsuyoshi  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Professor, 医学研究科, 教授 (70134103)

Co-Investigator(Kenkyū-buntansha) SASAJIMA Hiroyasu  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Associate Professor, 医学研究科, 助教授 (80196188)
OHWADA Kei  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (80332948)
KIMURA Satoshi  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (00301424)
KAWABE Takuya  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (10360033)
KURIOKA Hiroki  Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (30405295)
Project Period (FY) 2004 – 2005
Keywordsbrain tumors / molecule-targeting therapy / logistics / malignancy / localization / PET / F-18-fluorodeoxyglucose / F-18-B-10-fluoroboronophenylalanine
Research Abstract

Determination of therapeutic management of brain tumors is based on both host factors of individual patients and tumor factors. Current development in functional neuroimaging such as PET characterizes in vivo tumor factors including physiological and biochemical process of brain tumors.
To test in vivo transport system and tumor proliferation of meningiomas, kinetic analysis using ^<18>F-fluorodeoxyglucose (FDG) or ^<18>F-fluoroboronophenylalanine-was obtained and compared with immunoreactivity to vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1). K1 was higher in meningiomas than in gliomas, and was higher in atypical than in benign meningiomas. k3 was correlated with a proliferating index, MIB-1 LI, in meningiomas. Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas, but atypical meningiomas stained more intensely than benign meningiomas. High values for K1 and k3 indicate the aggressive proliferation of meningiomas, and in a … More typical meningiomas, the synergistic interaction of the high permeability and the large surface area yielded conditions conducive to glucose metabolism and tumor proliferation.
The uptake and distribution of FDG is important landmark for malignancy and tumor extent. The tumor portion including a peak FDG uptake portion is a target for accurate diagnosis of malignancy. High-grade gliomas show heterogeneous uptake patterns, reflecting a topographic variation of cellular composition consisting of aggregated tumor cells, necrosis, and peritumoral edema. Among mostly benign tumors such as meningioma and central neurocytoma, atypical subsets have a relatively high uptake of FDG. The maximum reduction of tumor mass may be applied, when atypical.
The present study indicates that logistic support factors enhance tumor growth including tumor angiogenesis. Clinical use of functional image less invasively provides multidisciplinary biologic characteristics and leads to more appropriate treatment based on the tumor factors, and may result in prolonging high levels of performance status in brain tumors. Less

  • Research Products

    (20 results)

All 2006 2005 2004

All Journal Article (20 results)

  • [Journal Article] Clinical significance of positron emission tomography in brain tumor surgery2006

    • Author(s)
      Mineura K
    • Journal Title

      Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. (Kanno T (ed)) (Spriger-Verlag, Tokyo)

      Pages: 73-79

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 代謝2006

    • Author(s)
      峯浦一喜
    • Journal Title

      グリオーマ-病態と治療-.(田渕和雄(編))(シュプリンガーフェアラーク東京)

      Pages: 93-102

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical significance of positron emission tomography in brain tumor surgery.2006

    • Author(s)
      Mineura K
    • Journal Title

      Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology.(Kanno T, Kato Y(eds.))(Spriger-Verlag, Tokyo)

      Pages: 73-79

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Metabolism.2006

    • Author(s)
      Mineura K, Tatsuzawa K, Aita K
    • Journal Title

      Gliomas. Research and Therapy.(Tabuchi K(ed))(Springer-Verlag, Tokyo)(in Japanese)

      Pages: 93-102

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 両側内頚動脈狭窄・閉塞症に対する外科的血行再建術および血管内治療の併用療法2005

    • Author(s)
      井上靖夫
    • Journal Title

      脳卒中 27・2

      Pages: 292-293

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Positron emission tomography elucidates transport system and tumor proliferation in meningiomas2005

    • Author(s)
      Murakami M
    • Journal Title

      Oncol Res 14・8

      Pages: 853-859

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] PETによる分子画像の新潮流2005

    • Author(s)
      今堀良夫
    • Journal Title

      日本臨床 63・増刊

      Pages: 11-18

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 前頭側頭開頭(pterional approach)の手術手技2005

    • Author(s)
      峯浦一喜
    • Journal Title

      脳神経外科学大系(山浦晶(編))(中山書店) 3

      Pages: 64-88

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 脳機能マッピングを利用したeloquent area近傍転移性脳腫瘍の手術2005

    • Author(s)
      立澤和典
    • Journal Title

      脳腫瘍の外科(山下純宏(編))(メディカ出版)

      Pages: 76-82

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Combination of surgical and endovascular treatments for bilateral carotid occlusive disease.2005

    • Author(s)
      Inoue Y, Houri T, Ueda S, Osaka Y, Tenjin H, Mineura K
    • Journal Title

      Jpn J Stroke(in Japanese) 27

      Pages: 292-298

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Positron emission tomography elucidates transport system and tumor proliferation in meningiomas.2005

    • Author(s)
      Murakami M, Imahori Y, Kimura S, Tatsuzawa K, Ohwada K, Inoue Y, Sasajima H, Mineura K
    • Journal Title

      Oncol Res 14

      Pages: 853-859

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular imaging for brain tumor using positron emission tomography.2005

    • Author(s)
      Imahori Y, Sasajima H, Mineura K
    • Journal Title

      Nippon Rinsho(in Japanese) 63

      Pages: 250-257

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surgical technique of frontotemporal (pterional) craniotomy.2005

    • Author(s)
      Mineura K, Sasajima H, Ohwada K
    • Journal Title

      Neurosurgery. vol 3. Basic Surgical Technique, Anatomy, and Anesthesia.(Yamaura A(ed.))(Nakayamashoten, Tokyo)(in Japanese)

      Pages: 64-88

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surgery for metastatic brain tumors located at/adjacent to the eloquent area using functional MRI brain mapping.2005

    • Author(s)
      Tatsuzawa K, Sasajima H, Ohwada K, Inoue Y, Mineura K, Yamada K
    • Journal Title

      Brain Tumor Surgery.(Yamashita J(ed.))(Medica Publication, Osaka)(in Japanese)

      Pages: 76-82

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 運動の高次脳機能イメージング2004

    • Author(s)
      峯浦一喜
    • Journal Title

      臨床スポーツ医学 21・9

      Pages: 1047-1055

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 高齢者眼窩内腫瘍の手術2004

    • Author(s)
      大和田敬
    • Journal Title

      Geriatric Neurosurgery 16

      Pages: 97-100

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 不安障害におけるPET所見と臨床心理学的評価2004

    • Author(s)
      今堀良夫
    • Journal Title

      Progress in Medicine 11・11

      Pages: 3016-3019

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Higher cerebral function imaging of movement.2004

    • Author(s)
      Mineura K, Sasajima H, Imahori Y.
    • Journal Title

      Clinical Medicine of Sport Medicine(in Japanese) 21

      Pages: 1047-1055

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surgical treatment of intraorbital tumors using a transcranial orbitofrontal approach in the eldery.2004

    • Author(s)
      Ohwada K, Sasajima H, Tatsuzawa K, Mineura K
    • Journal Title

      Geriatric Neurosurgery(in Japanese) 16

      Pages: 97-100

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] PET findings and clinicopsychologic evaluation in anxious disturbance.2004

    • Author(s)
      Imahori Y, Maekawa M, Ohwada K, Sasajima H, Mineura K
    • Journal Title

      Progress in Medicine(in Japanese) 11

      Pages: 3016-3019

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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