2007 Fiscal Year Final Research Report Summary
Neural mechanisms of drug-seeking behavior elicited by drug-associated environmental stimuli and development of new strategy to prevent conditioned stimulus-elicited drug-seeking
| Project/Area Number |
16591166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MIYATA Hisatsugu Jikei University School of Medicine, Department of Medicine, Associate Professor (70239416)
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Minako The Jikei University, Department of Medicine, Assistant Professor (30277032)
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| Project Period (FY) |
2004 – 2007
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| Keywords | nicotine / conditioned place preference / intracranial self-stimulation / conditioned stimulus / brain reward system / medial forebrain bundle / lateral hypothalamus / rat |
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| Research Abstract |
The purpose of the present study was to investigate the involvement of environmental stimuli associated with nicotine (NCT) in NCT dependence. In a conditioned place preference (CPP) paradigm, NCT-associated environmental stimuli maintained a place preference for NCT up to 6 months. Destruction of DA system with 6-OHDA in the basolateral amygdala (AMY) and ventral tegmental area (VTA) decreased a place preference for NCT elicited by NCT-associated environmental stimuli. Disruption of CPPs elicited by NCT-associated environmental stimuli in rats treated with 6-OHDA was reversed by administration of the training dose of NCT (0.4 mg/kg, s.c.). In an intracranial self-stimulation (ICSS) paradigm, NCT-associated environmental stimuli decreased lateral hypothalamus ICSS thresholds, whereas NCT-unrelated environmental stimuli did not. BP 897, a D3 partial agonist, administered prior to the conditioning sessions with NCT tended to block an ability of NCT-associated environmental stimuli to decrease medial forebrain bundle ICSS thresholds. These results indicate 1) the environmental stimuli associated with NCT function as powerful cues to maintain NCT-seeking behavior through stimulating a brain reward system, 2) the AMY and the VTA DA system are involved in NCT-seeking behavior elicited by the environmental stimuli associated with NCT, 3) BP 897 is a candidate as a new drug to prevent NCT-seeking behavior by blocking an association between NCT and the environmental stimuli.
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Research Products
(30 results)
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[Journal Article] Psychosocial withdrawal characterictice of nicotine compared with alcohol and caffeine2008
Author(s)
Miyata, Hiyata, Hironaka, Naoyuki, Takada, Kohji, Miyasato, Katsumasa, Nakamura, Kohichi, Yanagita, Tomoji
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Journal Title
Annals of the New York Academy of Sciences (in press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Psychosocial withdrawal characterictice of nicotine compared with alcohol and caffeine2007
Author(s)
Miyata, Hiyata, Hironaka, Naoyuki, Takada, Kohji, Miyasato, Katsumasa, Nakamura, Kohichi, Yanagita, Tomoji
Organizer
1st Annual International Drug Abuse Research Society and International Society for Neurochemistry Satellite Meeting
Place of Presentation
Merida(Mexico)
Year and Date
2007-08-08
Description
「研究成果報告書概要(欧文)」より
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