2006 Fiscal Year Final Research Report Summary

5-aminolevulinic acid mediated photodynamic therapy for oral precancerous lesions

Research Project

Project/Area Number	16591990
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	TANAKA Hideo Hamamatsu University School of Medicine, University Hospital, Department of Oral and Maxillofacial Surgery, Assistant Professor, 医学部附属病院, 助手 (30362205)
Co-Investigator(Kenkyū-buntansha)	HASHIMOTO Kenji Hamamatsu University School of Medicine, Department of Oral and Maxillofacial Surgery, Professor, 医学部, 教授 (60094166) KATOU Fuminori Hamamatsu University School of Medicine, Department of Oral and Maxillofacial Surgery, Associate Professor, 医学部, 助教授 (60204492)
Project Period (FY)	2004 – 2006
Keywords	Photodynamic therapy / 5-aminolevulinic acid / Oral precancerous lesions
Research Abstract	5-aminorevulinic acid was administered topically to the tongue of rabbit. Even when medicine was washed away about 10 minutes after topical application, protoporfirin IX accumulated to almost same degree with conventional application methods. Fluorescence micrography to evaluate drug localization revealed that protoporfirin accumulate mucosal basal layer. The result suggest that 5-aminorevulinic acid mediated photodynamic therapy will be efficient therapy for oral leukoplakia.

(4 results)