2008 Fiscal Year Final Research Report
Experimental and mathematical analyses of biological pattern formation
| Project/Area Number |
16GS0307
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Osaka University (2008)
Nagoya University (2004-2007) |
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Principal Investigator |
KONDO Shigeru Osaka University, 大学院・生命機能研究科, 教授 (10252503)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Koichi 国立遺伝学研究所, 個体遺伝研究系初期発生研究部門, 教授 (70195048)
WATANABE Masakatsu 大阪大学, 大学院・生命機能研究科, 准教授 (90323807)
MIYAZAWA Seita 大阪大学, 大学院・生命機能研究科, 助教 (10377905)
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| Project Period (FY) |
2004 – 2008
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| Keywords | ゼブラフィッシュ / 反応拡散 / チューリング / パターン形成 / 色素細胞 |
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| Research Abstract |
The following results were obtained for Zebra fish's skin pattern formation mechanism.
1) The network of the interaction among the pigment cells was clarified.
2) The computational simulation that built in the network reproduced the process of skin pattern formation accurately.
3) The responsible genes for the mutants were identified
4) The cloned genes were K channel and a gap junction.
5) By making the transgenics fish with the genes or modified ones, the pattern was changed in many different way, suggesting that the genes were core factors of the pattern formation.
6) The ion channels and the small molecules play the key rolein the pattern formation. From above, we have come close to the clarification of the mechanism of pigment pattern formation.
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