2018 Fiscal Year Final Research Report
Selective antibacterial activity of peptide nucleic acid against Streptococcus pneumoniae
| Project/Area Number |
16K10016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 肺炎球菌 / アンチセンス / ペプチド核酸 / 必須遺伝子 / 薬剤耐性 |
|---|
| Outline of Final Research Achievements |
To assess antibacterial activity against Streptococcus pneumoniae, we designed PNA-peptides. A PNA-peptide （RFR-acpP-PNA2S）that targets acpP, has a 5′ membrane-penetrating peptide and has a linker shows excellent activity against planktonic Streptococcus pneumoniae（MIC 5μmol/L）.
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| Free Research Field |
感染症
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| Academic Significance and Societal Importance of the Research Achievements |
従来の抗菌薬はその濫用により耐性化が問題となっている。本研究で開発した新しい抗菌薬であるPNAは、肺炎球菌だけが持つ遺伝子配列をターゲットにすることで同菌を選択的に除菌することができる。
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