Mechanistic studies to analyze the pathophysiology of ISSNS in children

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Jichi Medical University
• Principal Investigator: Kanai Takahiro 自治医科大学, 医学部, 准教授 (00398504)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 小児特発性ステロイド感受性ネフローゼ症候群

Outline of Final Research Achievements

This study was aimed to investigate the role of STAT5B in pediatric idiopathic steroid-sensitive nephrotic syndrome and to reveal the pathophysiology, then to contribute to develop new medicines for this disease.
ChIP-seq technique was applied for this study, using the patients’ paired-peripheral blood mononuclear cells from nephrotic-phase before initiation of steroids and from remission phase without any medication.
Several peaks of binding-sites were detected. The peaks were statistically different between nephrotic-phase and remission-phase. Some of them were the binding sites for vascular permeability, cellular or humoral immunity or lipid metabolism.

Free Research Field

小児腎臓病

Academic Significance and Societal Importance of the Research Achievements

本研究により、小児特発性ステロイド感受性ネフローゼ症候群の病態の一部を解明する手掛かりを得ることができた。本研究を進めることで、原因のさらなる解明を行うことができると思われる。