A novel role of adhesion-GPCR in synaptic functions and motor learning.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15183
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: Kakegawa Wataru 慶應義塾大学, 医学部(信濃町), 准教授 (70383718)
• Co-Investigator(Renkei-kenkyūsha): Yuzaki Michisuke 慶應義塾大学, 医学部, 教授 (40365226) ; Miura Eriko 慶應義塾大学, 医学部, 研究員 (10571169) ; Motohashi Junko 慶應義塾大学, 医学部, 研究員 (10407083)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 細胞接着 / Gタンパク質共役型受容体 / シナプス / 記憶・学習

Outline of Final Research Achievements

Recently, adhesion-type G protein-coupled receptors (ADGRs) have been intensively studied as molecules which regulate synapse integrity and learning & memory in the CNS. ADGR has a unique structure which contains an extracellular N-terminal domain with various types of functional domains, a seven-transmembrane region and an intracellular domain interacting with several signal molecules including G proteins. Despite its unique structure, the mechanisms by which ADGR behaves at synapses have remained unclear. In this study, we demonstrated that a brain-specific angiogenesis inhibitor 3 (BAI3), an ADGR member abundantly expressed at the synapses between climbing fiber (CF) and Purkinje cell in the cerebellum, plays crucial roles in synapse morphology, synaptic plasticity and cerebellar motor learning.

Free Research Field

神経生理学