Development of a real-time optical thrombus sensor for an extracorporeal centrifugal blood pump using visible and near-infrared spectroscopy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16384
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: FUJIWARA Tatsuki 東京医科歯科大学, 医学部附属病院, 助教 (00632291)
• Research Collaborator: SAKOTA Daisuke 国立研究開発法人 産業技術総合研究所, 健康工学研究部門, 主任研究員 (40588670)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 体外循環 / 補助循環 / 血栓検出 / 血液凝固識別装置 / 遠心ポンプ / ジャイロポンプ / 心臓血管外科

Outline of Final Research Achievements

Pump thrombus remains the weak point of mechanical circulatory support. We have developed a new method for optical continuous monitoring of pump thrombus. This study applied a gyro centrifugal pump. The top pivot bearing is an area at particularly high risk of thrombus formation due to the stagnation of circulating blood. We used visible and near-infrared spectroscopy. The top bearing was illuminated directly overhead by a xenon lamp guided by the incident optical fiber. The scattered light was detected by the detection optical fiber placed at right angles to the incident optical fiber, and was analyzed using a spectrophotometer connected to the detection optical fiber.
The system succeeded in real-time monitoring of thrombus formation for both in-vitro and animal experiments using swine as a left ventricular assist device model. This method showed the feasibility of non-invasive, continuous monitoring of pump thrombus without the influence of either oxygen saturation or hematocrit.

Free Research Field

心臓血管外科