2017 Fiscal Year Final Research Report
Elucidate the role of inflammasome in irradiation-induced enteritis
| Project/Area Number |
16K19846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 放射線腸炎 / インフラマソーム / IL-1β |
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| Outline of Final Research Achievements |
Inflammation plays an important role in the pathogenesis of irradiation-induced enteritis; however, it is still unknown how radiation triggers its inflammatory responses after irradiation. We hypothesized that NLRP3 inflammasomes, a newly innate immune pathway, are involved in the process of irradiation-induced enteritis., and found that compared to the wild-type mice, mice deficient of inflammasome components prolonged the survival time, and reduced body weight loss and the expression of inflammatory and fibrosis-related markers. Furthermore, cohousing experiments revealed that gut microbiota, especially Helicobacter, contributes to the pathogenesis of irradiation-induced enteritis. These findings suggest that NLRP3 inflammasomes are crucial for mediating irradiation-induced enteritis and Helicobacter may be involved in its process.
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| Free Research Field |
消化器外科
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