Molecular basis study for revealing the pathogenesis of NAFLD after pancreatic resection focusing on extracellular matrix

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19917
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Kato Hiroyuki 三重大学, 医学部附属病院, 助教 (50737004)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 膵頭十二指腸切除 / 細胞外マトリックス / NAFLD

Outline of Final Research Achievements

We performed the study to prove the etiology of development of NASH after a pancreaticoduodenectomy (PD) using mice or rat PD models. Even in mice and rat PD model, significant liver injury and fat deposition to the liver parenchyma and sinusoidal injury as evidenced by PECAM-1 depression were seen at the 24 hours after PD. Nevertheless, we observed the phenomenon that mice and rat markedly lost their appetite, resulting in death. However, In rat PD model, the level of TNF-a mRNA, neutrophil infiltration and monocytes infiltration in liver are significantly potentiated, with compared to the SHAM model.In conclusion, MMP-9 upregulation might be associated with the development of NAFLD after PD.

Free Research Field

肝胆膵移植外科