Establishment of single-cell thermodynamics and its expansion(Fostering Joint International Research)

2019 Fiscal Year Final Research Report

• Project/Area Number: 16KK0105
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Osaka University (2017, 2019); Waseda University (2016)
• Principal Investigator: Suzuki Madoka 大阪大学, 蛋白質研究所, 講師 (40350475)
• Project Period (FY): 2017 – 2019
• Keywords: 生物物理 / ナノ材料 / ナノバイオ / タンパク質 / 細胞 / 組織 / 蛍光顕微鏡

Outline of Final Research Achievements

The "base-project" has been going as planned at the single-cell level. The current project aimed to expand the base-project to both larger and smaller scales. The biological significance of the heat as a mean of intra- and intercellular communications ("thermal signaling" hypothesis) has been tested by the project. We have successfully achieved the goal of individual objectives set at the beginning of the current project.

Free Research Field

生物物理学・細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本国際共同研究課題では、最終的に、1細胞レベルの温度を、組織・個体から細胞内小器官レベルまで、広いスケールで扱う技術の開発と、1細胞レベルの温度がこれらスケールで果たす生理的な役割について検討を進め、「熱シグナル仮説」を強く裏付ける結果を得ることができた。研究代表者を中心として、将来にわたってアジアとヨーロッパをつなぐ研究連携が構築されたと考える。