Chemoprevention of colorectal cancer by targeting ACF

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015039
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Sapporo Medical University
• Principal Investigator: YOSHIRO Niitsu Sapporo Medical University, 分子標的探索講座, 特任教授 (10045502)
• Co-Investigator(Kenkyū-buntansha): TETSUJI Takayama 徳島大学, 大学院・ヘルスバイオサイエンス部, 教授 (10284994)
• Project Period (FY): 2005 – 2009
• Keywords: 大腸癌 / 予防 / ACF

Research Abstract

In the present study, we conducted a chemopreventive trial on colorectal cancer, using ACF, precursors of polyps, as surrogate lesions, and results clearly indicate that administration of sulindac for 2 months gave rise to almost equal effectiveness as those of previously reported trials in which sulindac was administered for years. We also performed animal experiment using mouse colon carcinogenesis model to examine the effect of inhibitor to GST-π which was highly expressed in ACF, and found a dramatic prevention effect on colon cancer development. Thus an approach to target GST-π in ACF is a promising modality for chemoprevention of colorectal cancer.

Research Products

• [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms. (2009)
  • Author(s): Hayashi T, Ishiwatari H, Ihara H, Kawano Y, Takada K, Miyanishi K, Kobune M, Takimoto R, Sonoda T, Takayama T, Kato J, Niitsu Y
  • Journal Title: J Gastroenterol 44(9) Pages: 964-75
  • Peer Reviewed
• [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis. (2008)
  • Author(s): Kukitsu T, Takayama T, Miyanishi K, Nobuoka A, Katsuki S, Sato Y, Takimoto R, Matsunaga T, Kato J, Sonoda T, Sakamaki S
  • Journal Title: Clin Cancer Res 14(1) Pages: 48-54
  • Peer Reviewed
• [Journal Article] Colorectal cancer: genetics of development and metastasis. (2006)
  • Author(s): Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y
  • Journal Title: J Gastroenterol 41(3) Pages: 185-92
  • Peer Reviewed
• [Journal Article] Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness. (2005)
  • Author(s): Takayama T, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y
  • Journal Title: Clin Gastroenterol Hepatol 3(7Suppl1) Pages: S42-5
  • Peer Reviewed
• [Presentation] Aberrant Cypt Foci:Detection, Genetic Abnormalities, and Clinical Usefulness (2009)
  • Author(s): 新津洋司郎
  • Organizer: SIDDS
  • Place of Presentation: KORIA
  • Year and Date: 2009-11-18
• [Presentation] 臨床家からのTranslational Research新津洋司郎 (2009)
  • Author(s): 新津洋司郎
  • Organizer: 仙台メトロポリタン講演会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-26