Control of critical period development in mouse somatosensory cortex by glutamatergic signal transduction

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17300108
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: HOKKAIDO UNIVERSITY
• Principal Investigator: WATANABE Masahiko Hokkaido Univ., Graduate School of Medicine, Prof, 大学院医学研究科, 教授 (70210945)
• Project Period (FY): 2005 – 2006
• Keywords: glutamate / receptor / barrel / plasticity / critical period

Research Abstract

In the present study, I studied on the molecular mechanisms regulating critical period development of the mouse somatosensory cortex using gene knockout mice. In particular, I focused on the roles played by NMDA-type glutamate receptor subunits GluRe2 (NR2B) and GLuRe4 (NR2D) and also by glutamate transporter GLAST and GLT1 in developmental appearance, critical period termination, critical period plasticity of somatosensory barrel structures. Here I found that, compared to wild-type control mice, heterozygous GlnRe2+/-mice showed one-day retardation in developmental appearance and critical period termination, whereas homozygous GluRe4-/-mice did on-day facilitation. No significant change was seen in the magnitude of critical period plasticity, as determined by row-C whisker cautery. In contrast, homozygous GLAST-/-and GLTI-/-mice displayed significant reduction in the magnitude of critical period plasticity, with normal developmental appearance and critical period termination. These results provide experimental evidence that N3IDA receptor activation regulates temporal properties of somatosensory development in a subunit-dependent manner, while transporters regulating extracellular glutamate concentration magnify critical period plasticity. Therefore, armed with the two mechanisms, synaptic refinement during development is shaped normally in a activity-dependent manner.

Research Products

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  • Description: 「研究成果報告書概要(欧文)」より
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• [Journal Article] Depolarization-induced suppression of inhibition mediated by endocannabinoid at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. (2006)
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  • Description: 「研究成果報告書概要(欧文)」より
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• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
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• [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. (2005)
  • Author(s): Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashimal T, Terasaki T
  • Journal Title: J. Neurochem. 95 Pages: 294-304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1-nock-out mice. (2005)
  • Author(s): Wu Y, Kawakami R, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R
  • Journal Title: J. Neurosci. 25 Pages: 9213-9226
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa S, Miyazaki T, lino M, Watanabe M, Kano M
  • Journal Title: Proc. Natl. Acad. Sci., USA 102 Pages: 19180-19185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.
  • Author(s): Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukais C, Kitagaki S, Miyakoshi N, Terasaki T
  • Journal Title: Pharmacol. Res. 23 Pages: 1235-1242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.
  • Author(s): Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K
  • Journal Title: Mol. Cell. Biochem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] umber and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replica labeling.
  • Author(s): Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R
  • Journal Title: J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phospholipase CB3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets.
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats.
  • Author(s): Takagishi Y, Hashimoto H, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, Kano M, Murata Y
  • Journal Title: J. Neurobiol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly.
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ca^<2+> permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination.
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.
  • Author(s): Takasaki C, Miura E, Watanabe M
  • Journal Title: Biomed Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より