2007 Fiscal Year Final Research Report Summary
Development of new treatment for severe liver diseases using platelets
| Project/Area Number |
17390359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHKOHCHI Nobuhiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, professor (40213673)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Michitaka University of Hokkaido, Graduate School of Medicine, professor (80256510)
TANIGUCHI Hideki Yokohama City University, Department of Regenerative Medicine, professor (70292555)
YASUE Hiroshi National Institute of Agrobiological Sciences, Associate director (80113497)
FUKUNAGA Kiyoshi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (20361339)
MURATA Soichiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (40436275)
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| Project Period (FY) |
2005 – 2007
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| Keywords | liver / platelet / treatment of liver failure / Kupffer cell / regeneration / Akt / thrombopoietin / anti-platelet antibody |
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| Research Abstract |
The aim of this research is to develop new treatment strategy of liver regeneration and liver failure using platelet function of hepato-proliferative effect. In 2005, we revealed that platelets promote liver regeneration after hepatectomy using mice. Platelets had direct effect on hepatocytes proliferation via PI3 kinase/Akt pathway. In 2006, we revealed that platelets promote liver regeneration after excessive hepatectomy. We also revealed that HGF and IGF-1 in platelets are the main effector of hepatocytes proliferation. To preserve platelets for a long time, we created a freeze dried platelet which preserved its shape, growth factors, and the effect of hepatocyte proliferation. In 2007, we revealed that platelets prevent progression of fibrosis and promote liver regeneration in cirrhotic rats and mice. The mechanism of reducing fibrosis by platelets was reducing TGF beta and increasing MMP-9 expression. In this research, we indicated that platelets and platelet products would be effective in liver cirrhosis treatment. We will continue clinical studies for treating severe liver diseases using platelets
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Research Products
(86 results)
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[Journal Article] Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro2008
Author(s)
R Matsuo, N Ohkohchi, S Murata, O Ikeda, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kubota, H Narimatsu, M Ozaki
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Journal Title
Journal of Surgical Research 145
Pages: 279-286
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Platelet dynamics in the early phase of post-ischemic liver in vivo Journal of Surgical Research
Author(s)
Y Nakano, T Kondo, R Matsuo, I Hashimoto, T Kawasaki, K Kouno, A Myronovych, S Tadano, K Hisakura, O Ikeda, M Watanabe, S Murata, N Ohkohchi
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Journal Title
Journal of Surgical Research (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Autonomic regulation of liver regeneration after partial hepatectomy in mice.
Author(s)
Ikeda, M Ozaki, S Murata, R Matsuo, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kawasaki, K Kohno, N Ohkohchi
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Journal Title
Journal of Surgical Research (in press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Treatment of fuhninant hepatitis by platelets2007
Author(s)
S Murata, K Hisakura, R Matuo, O Ikeda, A Myronovych, M Watanabe, Y Nakano, K Kouno, T Kawasaki, I Hashimoto, Y Shibasaki, K Fukunaga, N Ohkohchi
Organizer
The 14th the Japanese Society for the research of Hepatic Cells
Place of Presentation
Kagoshima
Year and Date
20070600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Development of new treatment for liver diseases using platelets2007
Author(s)
S Murata, A Myronovych, M Watanabe, K Hisakura, R Matsuo, 0 Ikeda, Y Nakano, K Kouno, T Kawasaki, I Hashimoto, Y Shibasaki, K Fukunaga, N Ohkohchi
Organizer
The 3rd Hiroshima Liver Project Research Center Symposium
Place of Presentation
Hiroshima
Year and Date
20070600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Kupffer cells promote liver regeneration2007
Author(s)
R Matsuo, S Murata, 0 Ikeda, Y Nakano, M Watanabe, K Hisakura, J Fukuzawa, S Tadano, N Ohkohchi
Organizer
The 107th Annual Congress of Japan Surgical Society
Place of Presentation
Osaka
Year and Date
20070400
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Platelets strongly promote hepatocyte proliferation2007
Author(s)
R Matsuo, S Murata, 0 Ikeda, Y Nakano, K Hisakura, M Watanabe, A Myronovych, T Kubota, H Narimatsu, M Ozaki, N Ohkohchi
Organizer
17th APASL
Place of Presentation
Kyoto
Year and Date
20070300
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Platelets promote liver regeneration after hepatectomy2006
Author(s)
S, Murata・R, Matsuo・O, Ikeda・R, Hoshi・A, Myronovych, M, Watanabe・K, Hisakura・Y, Nakano・N, Ohkohchi
Organizer
Fifth JSH Single Topic Conference
Place of Presentation
Nagasaki
Year and Date
20060929-30
Description
「研究成果報告書概要(和文)」より
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