2007 Fiscal Year Final Research Report Summary
Neuropathological analysis for siagnostic criteria of epileptogenic cerebral microdysgenesis
| Project/Area Number |
17500245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
ARAI Nobutaka Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Institute of Neuroscience, Staff scientist (10167984)
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| Project Period (FY) |
2005 – 2007
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| Keywords | intractable epilepsy / microdysgenssis / cerebral malformation / surgical pathology / functional neurosurgery / neuronal migrational disorder |
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| Research Abstract |
Existence of cerebral microdysgenesis is pointed out as a qualitative alteration of the focal cerebral lesion of intractable epilepsy. Existence of three kinds of views (superficial hypermyelination, subpial large neuron, persistent granule cell) was scored, and the sum total in each group and frequency were computed. As a result, the example with which three views coexisted went up to the abbreviation half, and it was suggested strongly that it was appropriate to diagnose it as microdysgenesis in such a case. Neuronal cytoskeletons (neurofilament, microtubule, microtubule-associated protein), glial cytoskeletons (GFAP, vimentin), calcium-binding proteins (calbindin, parvalbumin, calretinin), a GABA index (GAD) and phosphoryalted tau, ubiquitin, synuclerin, NMDAR-1, muscarinic acetylcholine receptor, myelin-associated glycoprotein etc. was stained on the microdysgenesis region. Moreover, it was shown clearly that the stainability by an anti-beta-catenin antibody is useful as a marker of diagnosis of occult cortical dysplasia. In addition, publication of the case reports and the textbook was performed about pathology change of the focal part of the abnormalities in brain formation which received the surgical treatment of intractable epilepsy.
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[Journal Article] A case of Sturge-Weber syndrome with severe temper tantrum,34(8),2006
Author(s)
Utsunomiya, T., Shimizu, H., Sunaga, S., Sugano, H.Arai, N.,
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Journal Title
No Shinkei Geka 34(8)
Pages: 819-24
Description
「研究成果報告書概要(和文)」より
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[Presentation] 皮質形成異常の周辺病変像2006
Author(s)
新井信隆、宇都宮利史、須永茂樹、清水弘之
Organizer
第40回日本てんかん学会
Place of Presentation
金沢市
Year and Date
2006-09-29
Description
「研究成果報告書概要(和文)」より
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