Examination of high-resolution MRI and MR spectroscopy evaluating therapieutic effect of radiation therapy and chemotherapy in animal model.

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17591297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa Medical University
• Principal Investigator: MATOBA Munetaka Kanazawa Medical University, Department of medicine, assistant professor, 医学部, 助教授 (90288308)
• Co-Investigator(Kenkyū-buntansha): YOKOTA Hajime Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (30182695) ; OOGUCH Manabu Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (10176852)
• Project Period (FY): 2005 – 2006
• Keywords: irradiation / animal study / VX2 carcinoma / MRI / MR spectroscopy

Research Abstract

We assessed the role of the high-resolution MRI and ^1H-MRS evaluating the therapieutic effect of chemotherapy and radiation therapy for VX2 carcinoma in rabbits. The rabbits with VX2 carcinoma in the thigh were underwent MRI and ^1H-MRS at before, 3 days, 1 week, and 2 weeks after 30Gy irradiation and one shot chemotherapy. After taking postirradiation MRI and ^1H-MRS, rabbits were killed for histopathologic examination at each time interval.
The high-resolution MRI findings were correlated with the histopathological findings, however, the early stage of necrosis of tumor was not able to evaluate using the high-resolution MRI. On ^1H-MRS, the ratio of lactate / creatine was elevated in the early stage of necrosis of tumor.
It was suggested that ^1H-MRS was superior to high-resolution MRI evaluating the early stage of necrosis of VX2 carcinoma post chemotherapy and radiation therapy.
The ^1H-MRS might be superior evaluating the therapieutic effects earlier.