Chiral separation mechanism on the basis of the molecular conformation of helical polymers

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K05884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Osaka University
• Principal Investigator: Terao Ken 大阪大学, 理学研究科, 准教授 (60334132)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 光学分割 / 高分子 / らせん / 高速液体クロマトグラフィー / 光散乱 / 小角X線散乱 / 放射光

Outline of Final Research Achievements

Helical polymers, including amylose derivatives, were studied to obtain the following results. (1) It was clarified that the local helical structure of linear and ring chains in dilute solution are appreciably different from each other. (2) Chiral columns were prepared from cyclic and linear chains to determine the chiral separation ability. Remarkable difference in chiral separation ability were found between the cyclic and linear chains, indicating that the local helical structure of amylose derivatives plays an important role in chiral separation. (3) Lyotropic liquid crystallinity was found both for rigid star and rigid ring polymers in a concentrated solution, and furthermore, the molecular conformation in the concentrated solution was different from those in dilute solution.

Free Research Field

高分子溶液

Academic Significance and Societal Importance of the Research Achievements

線状鎖と環状鎖を用いることにより、剛直な高分子鎖の局所分子形態に有意な違いが生じることが明らかにされた。これらの高分子を用いて、光学活性な化合物の純度決定や分離に用いられるキラル分離カラムを調製したところ、その分離特性に大きな違いが見られた。キラル分離カラム中の高分子鎖の分子形態がキラル分離能に重要な役割を果たすことが明らかにされた。