Induction mechanism of antiviral factors in Kuruma shrimp

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K07953
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Aquatic life science
• Research Institution: Fisheries Research and Education Agency
• Principal Investigator: Mekata Tohru 国立研究開発法人水産研究・教育機構, 増養殖研究所, 主任研究員 (40597944)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: クルマエビ / 抗ウイルス応答

Outline of Final Research Achievements

In order to understand the behavior of antiviral response-related factors in the hemolymph of kuruma shrimp, the identification of the factors and construction of a detection method were examined. It was revealed that highly abundant proteins can be removed by mixing a certain polymer compound with hemolymph. Gene ontology enrichment analysis of hemocytes during the antiviral response confirmed that the transcript levels involved in ribosome biosynthesis and proteolysis was significantly altered.

Free Research Field

魚病学、生体防御学

Academic Significance and Societal Importance of the Research Achievements

クルマエビのウイルス病を防ぐために、免疫賦活剤や抗ウイルス薬が研究開発されている。エビ類の養殖では様々なウイルス病が蔓延しており、一刻も早い防除対策が望まれている。クルマエビの抗ウイルス作用を持つ物質が発見されているが、その作用機序は不明である。免疫賦活剤の実用化を進めていく上でも、その作用機序の解明が望まれている。