2019 Fiscal Year Final Research Report
Preparation and evaluation of smart polymer gel sheet as an innovative organ/skin wound dressing
| Project/Area Number |
17K08480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | キトサン / シクロデキストリン / 創傷治癒 / 硫酸化多糖類 / 徐放化 / 抗酸化作用 / 静電的相互作用 |
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| Outline of Final Research Achievements |
A safe and side-effect free ionic polymer was prepared as a gel sheet by combining surface-deacetylated chitin nanofibers (SDACNFs), sacran (Sac) and cyclodextrin (CyD). As a result, freeze dried Sac/SDACNFs pellets containing the tetrahydro-curcumin/2-hydroxypropyl-β-CyD complex has the potential for use as a new transdermal therapeutic system, from the viewpoints of the wound healing activity, slow release of the THC and the usability of pellets. Further, the prednisolone/SDACNFs/sulfobutyl ether-β-CyD gel has also the potential for use in the therapeutic treatment of colitis in colitis model mice. In future, these efficacy profiles of the SDACNFs/CyDs gel suggest that it has the potential for use in the treatment of, not only colitis, but also a variety of other disorders associated with inflammation and oxidative injuries.
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| Free Research Field |
医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
ガーゼ等の創傷被覆材は細胞増殖因子を含む体液まで吸収し，創傷治癒を遅らせる原因となることが報告されている．そこで，傷痕が残らずにより早く創傷を治癒させるためには，創傷部を湿潤環境に保つことが有効であり，ゲル状の創傷被覆材や臓器保護材の開発が進んでいる．さらに近年，これら創傷被覆材と薬物の併用による創傷治癒効果の促進が期待されており，薬物の効果を最大限に長時間維持するためには，創傷部における薬物の有効濃度を長時間一定に保つ必要がある．したがって，創傷部を適度に湿潤させ，かつ薬物保持効果を持つ安定なゲルシートの作製が望まれている．
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