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2008 Fiscal Year Final Research Report

Research of emission and international comparison of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in Pan-Japan Sea cities

Research Project

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Project/Area Number 18256002
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental pharmacy
Research InstitutionKanazawa University

Principal Investigator

HAYAKAWA Kazuichi  Kanazawa University, 薬学系, 教授 (40115267)

Co-Investigator(Kenkyū-buntansha) TORIBA Akira  金沢大学, 薬学系, 准教授 (50313680)
KAMEDA Takayuki  金沢大学, 薬学系, 助教 (50398426)
TOU Nei  金沢大学, 薬学系, 助教 (90372490)
Co-Investigator(Renkei-kenkyūsha) TAMURA Kenji  (独)国立環境研究所, 環境健康研究領域・疫学・国際保健研究室, 主任研究員 (10179898)
Project Period (FY) 2006 – 2008
Keywords多環芳香族炭化水素 / ニトロ多環芳香族炭化水素 / 発生源 / 長距離輸送 / 毒性 / 曝露 / 代謝
Research Abstract

本研究では, 環日本海域の主要大気汚染物質の一つである多環芳香族炭化水素(PAH)及びニトロ多環芳香族炭化水素(NPAH)について次の成果を得た。1) 大気中のガス状と粒子状とを分別捕集する装置を開発し, 実大気中の存在状態を明らかにした。2) 能登半島先端の大気中PAH及びフッ素の一部が中国から長距離輸送され, 前者は中国の冬季の石炭暖房, 後者は黄砂嵐が主発生要因であることを明らかにした。3) 最近の環日本海域の大気汚染傾向と毒性の強さ及びPAH,NPAH濃度との関係を明らかにした。4) ヒトのNPAHの曝露を, 尿中代謝物を用いて明らかにするLC-MS/MS分析法を開発した。これを用いて, 中国瀋陽市の住民(学童)の尿中1-NP代謝物は日本人より高いことを明らかにした。

  • Research Products

    (25 results)

All 2009 2008 2007 2006 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Exposures to particulate air pollution and nitro-polycyclic aromatic hydrocarbons amongst taxi drivers in Shenyang, China2009

    • Author(s)
      Miller-Schlze, J. P., Toriba, A., Tang, N., Hayakawa, K., Tamura, K., Dong, L., Simpson, C. D.
    • Journal Title

      Environ Sci. Technol 27

    • URL

      http://pubs.acs.orgonFeb

    • Peer Reviewed
  • [Journal Article] Analysis of atmospheric polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in gas/particle phases separately collected by a high-volume air sampler equipped with a column packed with XAD-4 resin2009

    • Author(s)
      Araki, Y., Tang, N., Ohno, M., Kameda, T., Toriba, A., Hayakawa, K.
    • Journal Title

      J. Health Sci 55(1)

      Pages: 77-85

    • Peer Reviewed
  • [Journal Article] Interaction of hydroxylated polycyclic aromatic hydrocarbons to estrogen receptor. Polycycl2008

    • Author(s)
      Hayakawa, K., Onoda, Y., Tachikawa, C., Yoshita, M., Toriba, A., Kameda, T., Tang, N.
    • Journal Title

      Aromat. Comp 28(4)

      Pages: 382-391

    • Peer Reviewed
  • [Journal Article] Cigrette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line2008

    • Author(s)
      Shizu, M., Itoh, Y., Sunahara, R., Chujo, S., Hayashi, H., Ide, Y., Takii, T., Koshiko, M., Chung, S. W., Hayakawa, K., Miyazawa, K., Hirose, K., Onozaki, K.
    • Journal Title

      J. Interferon Cytokine Res.,August 28(8)

      Pages: 509-522

    • Peer Reviewed
  • [Journal Article] Direct measurement of the glucuronide conjugate of 1-hydroxypyrene in human urine by using liquid chromatography with tandem mass spectrometry2008

    • Author(s)
      Kakimoto, K., Toriba, A., Ohno, T., Ueno, M., Kameda, T., Tang, N., Hayakawa, K
    • Journal Title

      J. Chromatogr. B 867

      Pages: 259-263

    • Peer Reviewed
  • [Journal Article] Evaluation of endocrine disrupting activities of monohydroxylated derivatives of 1-nitropyrene by yeast two-hybrid assay2008

    • Author(s)
      Kameda, T., Akiyama, A., Toriba, A., Tachikawa, C., Yoshita, M., Tang, N., Hayakawa, K.
    • Journal Title

      J. Health Sci 54(1)

      Pages: 18-22

    • Peer Reviewed
  • [Journal Article] PAH, NPAH, 変異原性および活性酸素種生成能から見た北九州と鉄嶺の大気汚染の比較2008

    • Author(s)
      戸次加奈江, 唐 寧, 鳥羽 陽, 早川和二
    • Journal Title

      産業医科大学雑誌 30(1)

      Pages: 39-45

    • Peer Reviewed
  • [Journal Article] Activation of 5-lipoxygenase and NF-κB in the action of acenaphthenequinone by modulation of oxidative stress2007

    • Author(s)
      Chung, S.-W., Toriba, A., Chung, H.-Y., Yu, B.-P., Kameda, T., Tang, N., Kizu, R., Hayakawa, K.
    • Journal Title

      Toxicol. Sci 101(1)

      Pages: 152-158

    • Peer Reviewed
  • [Journal Article] Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extract2007

    • Author(s)
      Noguchi, K., Toriba, A., Chung, S.-W., Kizu, R., Hayakawa, K.
    • Journal Title

      Biomed. Chromatogr 21(11)

      Pages: 1135-1142

    • Peer Reviewed
  • [Journal Article] Estrogenic/antiestrogenic activities of polycyclic aromatic hydrocarbons and their monohydroxylated derivatives by Yeast two-hybrid assay2007

    • Author(s)
      Hayakawa, K., Onoda, Y., Tachikawa, C., Hosoi, S., Yoshita, M., Chung, S.-W., Kizu, R., Toriba, A., Kameda, T., and Tang, N.
    • Journal Title

      J. Health Sci 53(5)

      Pages: 562-570

    • Peer Reviewed
  • [Journal Article] Analysis of 1-nitropyrene in air particulate matter standard reference materials by using two-dimensional high performance liquid chromatography with online reduction and tandem mass spectrometry detection2007

    • Author(s)
      Miller-Schulze, J. P., Paulsen, M., Toriba, A., Hayakawa, K., Simpson, C. D.
    • Journal Title

      J. Chromatogr. A 1167

      Pages: 154-160

    • Peer Reviewed
  • [Journal Article] Identification and quantification of 1-Nitropyrene Metabolites in human urine as a proposed biomarker for exposure to diesel exhaust2007

    • Author(s)
      Toriba, A., Kitaoka, H., Dills, R., Mizukami, S., Tanabe, K., Takeuchi, N., Ueno, M., Kameda, T., Tang, N., Hayakawa, K., Simpson, C.
    • Journal Title

      Chem. Res. Toxicol 20(7)

      Pages: 999-1007

    • Peer Reviewed
  • [Journal Article] Long-range transportation of polycyclic aromatic hydrocarbons (PAHs) from the eastern Asian continent to Kanazawa, Japan with Asian dust2007

    • Author(s)
      Tamamura, S., Sato, T., Ota, Y., Wang, X., Tang, N., Hayakawa, K.
    • Journal Title

      Atmos. Environ 41(12)

      Pages: 2580-2593

    • Peer Reviewed
  • [Journal Article] Long-Range transportation of polycyclic aromatic hydrocarbons from China to Japan2007

    • Author(s)
      Yang, X.-Y., Okada, Y., Tang, N., Matsunaga, S., Tamura, K., Lin, J-M., Kameda,T., Toriba, A., Hayakawa, K.
    • Journal Title

      Atmos. Environ 41(13)

      Pages: 2710-2718

    • Peer Reviewed
  • [Journal Article] Profiles of particulate-bound polycyclic aromatic hydrocarbons and their nitrated derivatives in three typical cities2007

    • Author(s)
      Hattori, T., Tang, N., Tamura, K., Hokoda, A., Yang, X.-Y., Igarash K., Ohno, M., Okada, Y., Kameda, T., Toriba, A., Hayakawa, K.
    • Journal Title

      liaoning province, China, Environ. Forensics 8(1&2)

      Pages: 165-172

    • Peer Reviewed
  • [Journal Article] Determination of 1-nitropyrene metabolites by HPLC with chemiluminescence detection and its application to human urine as a new biomarker of exposure to diesel exhaust2006

    • Author(s)
      Hayakawa, K., Toriba, A., Lu, C., Mizukami, S., Kameda, T., Tang, N.
    • Journal Title

      Luminescence 21(6)

      Pages: 321-322

    • Peer Reviewed
  • [Journal Article] Simultaneous determination of urinary hydrxylated metabolites of naphthalene, fluorine, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbons2006

    • Author(s)
      Chetiyanukornkul, T., Toriba, A., Kameda, T., Tang, N., Hayakawa, K.
    • Journal Title

      Anal. Bioanal. Chem 386

      Pages: 712-718

    • Peer Reviewed
  • [Journal Article] Determination of 1-nitropyrene metabolites by high performance liquid chromatography with chemiluminescence detection2006

    • Author(s)
      Hayakawa, K., Lu, C., Mizukami, S., Toriba, A., Tang, N.
    • Journal Title

      J. Chromatogr. A 1107

      Pages: 286-289

    • Peer Reviewed
  • [Journal Article] Long-range transport of fluoride in East Asia monitored at Noto Penninsula

    • Author(s)
      Yang, X.-Y., Yamada, M., Tang, N., Lin J.-M., Kameda, T., Toriba, A., Hayakawa, K
    • Journal Title

      Japan, Sci., Total Environ (in press)

    • Peer Reviewed
  • [Journal Article] Determination of 1-nitropyrene in low volume anbient air samples by high-performance liquid chromatograph with fluorescence detection

    • Author(s)
      Ohno, T., Toriba, A., Kameda, T., Tang, N., Hayakawa, K
    • Journal Title

      J. Chromatogr. A (in press)

    • Peer Reviewed
  • [Presentation] Behaviors and toxicities of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons2008

    • Author(s)
      Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
    • Organizer
      12^<th> Asia Pacific Confederation of Chemical Engineering Congress
    • Place of Presentation
      Dalian, China
    • Year and Date
      20080804-06
  • [Presentation] Atmospheric behaviors and health effects of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in East Asias2007

    • Author(s)
      Hayakawa, K.
    • Organizer
      International Forum for Public Health, Shanghai 2007
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20071212-14
  • [Presentation] Monitoring and atmospheric behaviors of carrcinogenic/endocrine disrupting chemicals in East Asias : Polycyclic aromatic hydrocarbons and nitropolycyclic derivatives2007

    • Author(s)
      Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
    • Organizer
      4th Asian-Pacific international conference on pollutants' analysis and control
    • Place of Presentation
      Beijing, China
    • Year and Date
      20071010-15
  • [Presentation] Atmospheric behaviors of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in East Asia2007

    • Author(s)
      Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
    • Organizer
      The 2007 Environmental Societies Joint Conference
    • Place of Presentation
      Busan, Korea
    • Year and Date
      20070502-04
  • [Book] Past, Present and Future Environments of Pan-Japan Sea Region2006

    • Author(s)
      Hayakawa, K., Editorial Supervisor, Iwasaka, Y., Kanaoka, C., Kimura, S., Kizu, R., Toriba, A., Ibusuki, T., Komura, K., Yamamoto, M., Tazaki, K., Kawanishi, T., Arai S., Kato, M., Yatomi, C., Kamiya, T., Tsukawaki , S., Kashiwaya, K., Sato, T., Hasebe, N., Nakamura, K., Mikage, M., Sasayama, K., Kamata, N., Tnag, N.
    • Publisher
      (Chief Editor), Maruzen, Tokyo

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Published: 2010-06-10   Modified: 2016-04-21  

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