Visualization and quantification of microstructures of the brain: new concept using next-generation advanced diffusion MR imaging

2020 Fiscal Year Annual Research Report

• Project/Area Number: 18H02772
• Research Institution: Juntendo University
• Principal Investigator: 青木 茂樹 順天堂大学, 大学院医学研究科, 教授 (80222470)
• Co-Investigator(Kenkyū-buntansha): 下地 啓五 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20348931)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 拡散MRI / 拡散時間 / 脳 / 制限拡散 / microstructure / 拡散テンソル / 粘稠度 / epidermoid cyst

Outline of Annual Research Achievements

次世代拡散MRIによる脳微細構造の観察と定量として、短い拡散時間のOscillating gradient spin-echo(OGSE)を用い、微細構造変化が観察可能と思われる種々の病変に対して、検討を行った。従来の長い拡散時間の拡散強調像で高信号を呈する疾患で、短い拡散時間の拡散強調像で信号強度や見かけの拡散係数がどのように変化するかを検討した。従来の拡散強調像（長い拡散時間）による計測では、液体の粘稠度のみで拡散係数が短いものと、種々の構造により制限拡散が生じ拡散係数が短くなるものがともに高信号となるが、OGSEによる短い拡散時間では制限拡散によるものの一部（ちょうど拡散時間と微細構造がマッチした時）では、信号低下が起きることが予想され、微細構造が推定できる可能性を検討した。この研究は、実際にMRIの性能向上により、拡散強調像高信号が目立たなくなる疾患があることから発想した。類上皮腫(MRMS2018),急性期脳梗塞（Neurorad2018)、脈絡叢嚢胞(MRI2019), 脳腫瘍（MRI 2020), 脳梁膨大部病変（MRMS 2021),脳膿瘍(MRMS2022)およびファントム（JJR2018)で拡散時間の影響を調べた。これらは臨床における短い拡散時間を用いた微細構造研究として世界に先駆けるものであった。
拡散制限の原因として、類上皮腫の層状構造によるものが信号に影響を与えることが示される一方、急性期脳梗塞や腫瘍などでは現在のOGSE信号の低下は一部であった。制限拡散を起こす微細構造が現在のOGSEで観察できる5-10μmよりも小さいと考えられた。また、通常の撮像法でも拡散時間が短くなってきており、場合によってはコントラストが低下するため、拡散時間を考慮したプロトコールが望まれることも示された。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Imago7 Foundation, Pisa, Italy/IRCCS Stella Maris, Pisa, Italy/GE Healthcare, Munich, Germany(イタリア)
  • Country Name: ITALY
  • Counterpart Institution: Imago7 Foundation, Pisa, Italy/IRCCS Stella Maris, Pisa, Italy/GE Healthcare, Munich, Germany
• [Int'l Joint Research] MD Anderson Cancer Center,(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: MD Anderson Cancer Center,
• [Int'l Joint Research] University College London,(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University College London,
• [Journal Article] Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease (2021)
  • Author(s): Andica Christina、Kamagata Koji、Saito Yuya、Uchida Wataru、Fujita Shohei、Hagiwara Akifumi、Akashi Toshiaki、Wada Akihiko、Ogawa Takashi、Hatano Taku、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: npj Parkinson's Disease Volume: 7 Pages: －
  • DOI: 10.1038/s41531-021-00197-4
  • Peer Reviewed / Open Access
• [Journal Article] Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism (2021)
  • Author(s): Andica Christina、Kamagata Koji、Kirino Eiji、Uchida Wataru、Irie Ryusuke、Murata Syo、Aoki Shigeki
  • Journal Title: Molecular Autism Volume: 12 Pages: －
  • DOI: 10.1186/s13229-021-00456-4
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network (2021)
  • Author(s): Hagiwara Akifumi、Otsuka Yujiro、Andica Christina、Kato Shimpei、Yokoyama Kazumasa、Hori Masaaki、Fujita Shohei、Kamagata Koji、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Journal of Clinical Neuroscience Volume: 87 Pages: 55～58
  • DOI: 10.1016/j.jocn.2021.02.018
  • Peer Reviewed / Open Access
• [Journal Article] Effect of hybrid of compressed sensing and parallel imaging on the quantitative values measured by 3D quantitative synthetic MRI: A phantom study (2021)
  • Author(s): Murata Syo、Hagiwara Akifumi、Fujita Shohei、Haruyama Takuya、Kato Shimpei、Andica Christina、Kamagata Koji、Goto Masami、Hori Masaaki、Yoneyama Masami、Hamasaki Nozomi、Hoshito Haruyoshi、Aoki Shigeki
  • Journal Title: Magnetic Resonance Imaging Volume: 78 Pages: 90～97
  • DOI: 10.1016/j.mri.2021.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Low-Field Magnetic Resonance Imaging (2021)
  • Author(s): Hori Masaaki、Hagiwara Akifumi、Goto Masami、Wada Akihiko、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: 56 Pages: 669～679
  • DOI: 10.1097/RLI.0000000000000810
  • Peer Reviewed / Open Access
• [Journal Article] An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension (2021)
  • Author(s): Kikuta J.、Kamagata K.、Takabayashi K.、Taoka T.、Yokota H.、Andica C.、Wada A.、Someya Y.、Tamura Y.、Kawamori R.、Watada H.、Naganawa S.、Aoki S.
  • Journal Title: American Journal of Neuroradiology Volume: 43 Pages: 48～55
  • DOI: 10.3174/ajnr.A7334
  • Peer Reviewed / Open Access
• [Journal Article] Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study (2021)
  • Author(s): Taoka Toshiaki、Ito Rintaro、Nakamichi Rei、Kamagata Koji、Sakai Mayuko、Kawai Hisashi、Nakane Toshiki、Abe Takashi、Ichikawa Kazushige、Kikuta Junko、Aoki Shigeki、Naganawa Shinji
  • Journal Title: Japanese Journal of Radiology Volume: 40 Pages: 147～158
  • DOI: 10.1007/s11604-021-01187-5
  • Peer Reviewed / Open Access
• [Journal Article] Automation of a Rule-based Workflow to Estimate Age from Brain MR Imaging of Infants and Children Up to 2 Years Old Using Stacked Deep Learning (2021)
  • Author(s): Wada Akihiko、Saito Yuya、Fujita Shohei、Irie Ryusuke、Akashi Toshiaki、Sano Katsuhiro、Kato Shinpei、Ikenouchi Yutaka、Hagiwara Akifumi、Sato Kanako、Tomizawa Nobuo、Hayakawa Yayoi、Kikuta Junko、Kamagata Koji、Suzuki Michimasa、Hori Masaaki、Nakanishi Atsushi、Aoki Shigeki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: － Pages: －
  • DOI: 10.2463/mrms.mp.2021-0068
  • Peer Reviewed / Open Access
• [Journal Article] 3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions (2021)
  • Author(s): Fujita S.、Yokoyama K.、Hagiwara A.、Kato S.、Andica C.、Kamagata K.、Hattori N.、Abe O.、Aoki S.
  • Journal Title: American Journal of Neuroradiology Volume: 42 Pages: 471～478
  • DOI: 10.3174/ajnr.A6930
  • Peer Reviewed / Open Access
• [Journal Article] Neuronuclear and Neuromelanin‐Sensitive Imaging for Acquired Hepatocerebral Degeneration with Parkinsonism (2021)
  • Author(s): Ogawa Takashi、Ogaki Kotaro、Mori Yuko、Kamo Hikaru、Uchiyama Akira、Kamagata Koji、Nagaoka Masanori、Hattori Nobutaka
  • Journal Title: Movement Disorders Clinical Practice Volume: 8 Pages: 464～468
  • DOI: 10.1002/mdc3.13166
  • Peer Reviewed / Open Access
• [Journal Article] Possible Neuroprotective Effects of l-Carnitine on White-Matter Microstructural Damage and Cognitive Decline in Hemodialysis Patients (2021)
  • Author(s): Ueno Yuji、Saito Asami、Nakata Junichiro、Kamagata Koji、Taniguchi Daisuke、Motoi Yumiko、Io Hiroaki、Andica Christina、Shindo Atsuhiko、Shiina Kenta、Miyamoto Nobukazu、Yamashiro Kazuo、Urabe Takao、Suzuki Yusuke、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Nutrients Volume: 13 Pages: 1292～1292
  • DOI: 10.3390/nu13041292
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease (2021)
  • Author(s): Koinuma Takahiro、Hatano Taku、Kamagata Koji、Andica Christina、Mori Akio、Ogawa Takashi、Takeshige-Amano Haruka、Uchida Wataru、Saiki Shinji、Okuzumi Ayami、Ueno Shin-Ichi、Oji Yutaka、Saito Yuya、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Journal of Parkinson's Disease Volume: 11 Pages: 1221～1235
  • DOI: 10.3233/JPD-202495
  • Peer Reviewed / Open Access
• [Journal Article] Connectome analysis of male world‐class gymnasts using probabilistic multishell, multitissue constrained spherical deconvolution tracking (2021)
  • Author(s): Tomita Hiroyuki、Kamagata Koji、Andica Christina、Uchida Wataru、Fukuo Makoto、Waki Hidefumi、Sugano Hidenori、Tange Yuichi、Mitsuhashi Takumi、Lukies Matthew、Hagiwara Akifumi、Fujita Shohei、Wada Akihiko、Akashi Toshiaki、Murata Syo、Harada Mutsumi、Aoki Shigeki、Naito Hisashi
  • Journal Title: Journal of Neuroscience Research Volume: 99 Pages: 2558～2572
  • DOI: 10.1002/jnr.24912
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Brain Volume Measurements Made with 0.3- and 3-T MR Imaging (2021)
  • Author(s): Murata Syo、Hagiwara Akifumi、Kaga Hideyoshi、Someya Yuki、Nemoto Kiyotaka、Goto Masami、Kamagata Koji、Irie Ryusuke、Hori Masaaki、Andica Christina、Wada Akihiko、Kumamaru Kanako Kunishima、Shimoji Keigo、Otsuka Yujiro、Hoshito Haruyoshi、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Aoki Shigeki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: － Pages: －
  • DOI: 10.2463/mrms.tn.2020-0034
  • Peer Reviewed / Open Access
• [Journal Article] Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics (2021)
  • Author(s): Maekawa Tomoko、Hagiwara Akifumi、Yokoyama Kazumasa、Hori Masaaki、Andica Christina、Fujita Shohei、Kamagata Koji、Wada Akihiko、Abe Osamu、Tomizawa Yuji、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Neuroradiology Volume: 64 Pages: 465～471
  • DOI: 10.1007/s00234-021-02781-0
  • Peer Reviewed / Open Access
• [Journal Article] Parkinson’s disease: deep learning with a parameter-weighted structural connectome matrix for diagnosis and neural circuit disorder investigation (2021)
  • Author(s): Yasaka Koichiro、Kamagata Koji、Ogawa Takashi、Hatano Taku、Takeshige-Amano Haruka、Ogaki Kotaro、Andica Christina、Akai Hiroyuki、Kunimatsu Akira、Uchida Wataru、Hattori Nobutaka、Aoki Shigeki、Abe Osamu
  • Journal Title: Neuroradiology Volume: 63 Pages: 1451～1462
  • DOI: 10.1007/s00234-021-02648-4
  • Peer Reviewed / Open Access
• [Journal Article] Time-dependent Diffusion in Brain Abscesses Investigated with Oscillating-gradient Spin-echo (2021)
  • Author(s): Maekawa Tomoko、Hori Masaaki、Murata Katsutoshi、Feiweier Thorsten、Kamiya Kouhei、Andica Christina、Hagiwara Akifumi、Fujita Shohei、Kamagata Koji、Wada Akihiko、Abe Osamu、Aoki Shigeki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: － Pages: －
  • DOI: 10.2463/mrms.ici.2021-0083
  • Peer Reviewed / Open Access
• [Journal Article] White matter alterations in Parkinson's disease with levodopa-induced dyskinesia (2021)
  • Author(s): Ogawa Takashi、Hatano Taku、Kamagata Koji、Andica Christina、Takeshige-Amano Haruka、Uchida Wataru、Saito Yuya、Shimo Yasushi、Oyama Genko、Umemura Atsushi、Iwamuro Hirokazu、Ito Masanobu、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Parkinsonism & Related Disorders Volume: 90 Pages: 8～14
  • DOI: 10.1016/j.parkreldis.2021.07.021
  • Peer Reviewed / Open Access
• [Journal Article] White matter and nigral alterations in multiple system atrophy-parkinsonian type (2021)
  • Author(s): Ogawa Takashi、Hatano Taku、Kamagata Koji、Andica Christina、Takeshige-Amano Haruka、Uchida Wataru、Kamiyama Daiki、Shimo Yasushi、Oyama Genko、Umemura Atsushi、Iwamuro Hirokazu、Ito Masanobu、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: npj Parkinson's Disease Volume: 7 Pages: －
  • DOI: 10.1038/s41531-021-00236-0
  • Peer Reviewed / Open Access
• [Journal Article] Time-dependent Diffusion in Transient Splenial Lesion: Comparison between Oscillating-gradient Spin-echo Measurements and Monte-Carlo Simulation (2021)
  • Author(s): Maekawa Tomoko、Kamiya Kouhei、Murata Katsutoshi、Feiweier Thorsten、Hori Masaaki、Aoki Shigeki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 20 Pages: 227～230
  • DOI: 10.2463/mrms.bc.2020-0046
  • Peer Reviewed / Open Access
• [Journal Article] Accelerated Isotropic Multiparametric Imaging by High Spatial Resolution 3D-QALAS With Compressed Sensing (2020)
  • Author(s): Fujita Shohei、Hagiwara Akifumi、Takei Naoyuki、Hwang Ken-Pin、Fukunaga Issei、Kato Shimpei、Andica Christina、Kamagata Koji、Yokoyama Kazumasa、Hattori Nobutaka、Abe Osamu、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: 56 Pages: 292～300
  • DOI: 10.1097/RLI.0000000000000744
  • Peer Reviewed / Open Access
• [Journal Article] Repeatability and reproducibility of human brain morphometry using three‐dimensional magnetic resonance fingerprinting (2020)
  • Author(s): Fujita Shohei、Buonincontri Guido、Cencini Matteo、Fukunaga Issei、Takei Naoyuki、Schulte Rolf F.、Hagiwara Akifumi、Uchida Wataru、Hori Masaaki、Kamagata Koji、Abe Osamu、Aoki Shigeki
  • Journal Title: Human Brain Mapping Volume: 42 Pages: 275～285
  • DOI: 10.1002/hbm.25232
  • Peer Reviewed / Open Access
• [Journal Article] Age-Related Changes in Relaxation Times, Proton Density, Myelin, and Tissue Volumes in Adult Brain Analyzed by 2-Dimensional Quantitative Synthetic Magnetic Resonance Imaging (2020)
  • Author(s): Hagiwara Akifumi、Fujimoto Kotaro、Kamagata Koji、Murata Syo、Irie Ryusuke、Kaga Hideyoshi、Someya Yuki、Andica Christina、Fujita Shohei、Kato Shimpei、Fukunaga Issei、Wada Akihiko、Hori Masaaki、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: 56 Pages: 163～172
  • DOI: 10.1097/RLI.0000000000000720
  • Peer Reviewed / Open Access
• [Journal Article] Myelin and Axonal Damage in Normal-Appearing White Matter in Patients with Moyamoya Disease (2020)
  • Author(s): Hara S.、Hori M.、Hagiwara A.、Tsurushima Y.、Tanaka Y.、Maehara T.、Aoki S.、Nariai T.
  • Journal Title: American Journal of Neuroradiology Volume: － Pages: －
  • DOI: 10.3174/ajnr.A6708
  • Peer Reviewed / Open Access
• [Journal Article] Synthetic MRI and MR fingerprinting in routine neuroimaging protocol: What's the next step? (2020)
  • Author(s): Fujita Shohei、Hagiwara Akifumi、Aoki Shigeki、Abe Osamu
  • Journal Title: Journal of Neuroradiology Volume: 47 Pages: 134～135
  • DOI: 10.1016/j.neurad.2020.02.001
  • Peer Reviewed / Open Access
• [Journal Article] Deep Learning Approach for Generating MRA Images From 3D Quantitative Synthetic MRI Without Additional Scans (2020)
  • Author(s): Fujita Shohei、Hagiwara Akifumi、Otsuka Yujiro、Hori Masaaki、Takei Naoyuki、Hwang Ken-Pin、Irie Ryusuke、Andica Christina、Kamagata Koji、Akashi Toshiaki、Kunishima Kumamaru Kanako、Suzuki Michimasa、Wada Akihiko、Abe Osamu、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: 55 Pages: 249～256
  • DOI: 10.1097/RLI.0000000000000628
  • Peer Reviewed / Open Access
• [Journal Article] Brain White-Matter Degeneration Due to Aging and Parkinson Disease as Revealed by Double Diffusion Encoding (2020)
  • Author(s): Kamiya Kouhei、Kamagata Koji、Ogaki Kotaro、Hatano Taku、Ogawa Takashi、Takeshige-Amano Haruka、Murata Syo、Andica Christina、Murata Katsutoshi、Feiweier Thorsten、Hori Masaaki、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: －
  • DOI: 10.3389/fnins.2020.584510
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Deep Learning Approach with a 3D Convolutional Ladder Network for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease (2020)
  • Author(s): Irie Ryusuke、Otsuka Yujiro、Hagiwara Akifumi、Kamagata Koji、Kamiya Kouhei、Suzuki Michimasa、Wada Akihiko、Maekawa Tomoko、Fujita Shohei、Kato Shimpei、Nakajima Madoka、Miyajima Masakazu、Motoi Yumiko、Abe Osamu、Aoki Shigeki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 19 Pages: 351～358
  • DOI: 10.2463/mrms.mp.2019-0106
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI (2020)
  • Author(s): Maekawa Tomoko、Hori Masaaki、Murata Katsutoshi、Feiweier Thorsten、Kamiya Kouhei、Andica Christina、Hagiwara Akifumi、Fujita Shohei、Koshino Saori、Akashi Toshiaki、Kamagata Koji、Wada Akihiko、Abe Osamu、Aoki Shigeki
  • Journal Title: Magnetic Resonance Imaging Volume: 72 Pages: 34～41
  • DOI: 10.1016/j.mri.2020.06.018
  • Peer Reviewed / Open Access
• [Journal Article] Regional brain gray matter volume in world-class artistic gymnasts (2020)
  • Author(s): Fukuo Makoto、Kamagata Koji、Kuramochi Mana、Andica Christina、Tomita Hiroyuki、Waki Hidefumi、Sugano Hidenori、Tange Yuichi、Mitsuhashi Takumi、Uchida Wataru、Takenaka Yuki、Hagiwara Akifumi、Harada Mutsumi、Goto Masami、Hori Masaaki、Aoki Shigeki、Naito Hisashi
  • Journal Title: The Journal of Physiological Sciences Volume: 70 Pages: －
  • DOI: 10.1186/s12576-020-00767-w
  • Peer Reviewed / Open Access
• [Journal Article] Connectivity-based localization of human hypothalamic nuclei in functional images of standard voxel size (2020)
  • Author(s): Ogawa Akitoshi、Osada Takahiro、Tanaka Masaki、Kamagata Koji、Aoki Shigeki、Konishi Seiki
  • Journal Title: NeuroImage Volume: 221 Pages: 117205～117205
  • DOI: 10.1016/j.neuroimage.2020.117205
  • Peer Reviewed / Open Access
• [Journal Article] Image Domain Transfer by Deep Learning is Feasible in Multiple Sclerosis Clinical Practice (2020)
  • Author(s): Hagiwara Akifumi、Kamagata Koji、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: 55 Pages: 324～325
  • DOI: 10.1097/RLI.0000000000000665
  • Peer Reviewed / Open Access
• [Presentation] Time-Dependent Diffusion Using Oscillating-Gradient Spin-echo Sequence in Extra-Axial Brain Tumors (2021)
  • Author(s): Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Kouhei Kamiya, Christina Andica, Akifumi Hagiwara, Shohei Fujita, Koji Kamagata, Akihiko Wada, Shigeki Aoki.
  • Organizer: the 9th International Congress on MRI & 26th Annual Scientific Meeting of KSMRM (ICMRI 2021)
• [Presentation] Association of estimated time from the onset of multiple sclerosis plaques with myelin and axon-related quantitative MRI measurement. (2021)
  • Author(s): Tomoko Maekawa, Akifumi Hagiwara, Masaaki Hori, Christina Andica, Shohei Fujita, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition,
• [Presentation] Brain white and gray matter alterations in early-stage Parkinson's disease with GBA1 gene mutations evaluated using free water imaging. (2021)
  • Author(s): Andica C, Kamagata K, Abe M, Uchida W, Saito Y, Nozaki H, Takabayahi K, Hori M, Aoki S.
  • Organizer: 2021 ISMRM & SMRT Virtual Conference & Exhibition
• [Presentation] Comparison of cortical gray matter and subcortical gray matter using double diffusion encoding. (2021)
  • Author(s): Shimpei Kato, Kouhei Kamiya, Koji Kamagata, Hiroshi Kusahara, Masahiro Abe, Shohei Fujita, Toshiaki Akashi, Katsuhiro Sano, Akihiko Wada, Masaaki Hori, Osamu Abe, Shigeki Aoki.
  • Organizer: ISMRM & SMRT Annual Meeting & Exhibition 2021
• [Presentation] An investigation of the change in water diffusivity along the perivascular space in hypertensive patients2359 (2021)
  • Author(s): Junko Kikuta, Koji Kamagata, Kaito Takabayashi, Toshiaki Taoka, Hajime Yokota, Yuki Someya, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shinji Naganawa, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition
• [Presentation] Simultaneous morphometry and relaxometry of the human brain using three-dimensional MR fingerprinting at 1.5 and 3T. (2021)
  • Author(s): Shohei Fujita, Matteo Cencini, Guido Buonincontri, Naoyuki Takei, Rolf F. Schulte, Wataru Uchida, Akifumi Hagiwara, Koji Kamagata, Osamu Abe, Michela Tosetti, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition
• [Presentation] Prospective motion-corrected three-dimensional multiparametric mapping of the brain1371. (2021)
  • Author(s): Shohei Fujita, Naoyuki Takei, Akifumi Hagiwara, Issei Fukunaga, Dan Rettmann, Suchandrima Banerjee, Ken-Pin Hwang, Shiori Amemiya, Koji Kamagata, Osamu Abe, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition
• [Presentation] Radiomics with 3D MR fingerprinting: Influence of dictionary design on radiomic features and a potential mitigation strategy. (2021)
  • Author(s): Shohei Fujita, Akifumi Hagiwara, Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Shigeru Kiryu, Issei Fukunaga, Shimpei Kato, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition
• [Presentation] Temporal progression patterns of white-matter degeneration in CBS and PSP identified with Subtype & Stage Inference (SuStaIn). (2021)
  • Author(s): Yuya Saito, Peter A. Wijeratne, Koji Kamagata, Christina Andica, Wataru Uchida, Toshiaki Akashi, Akihiko Wada, Masaaki Hori, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition,
• [Presentation] Free Water Eliminated White Matter Tract Integrity of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder3446. (2021)
  • Author(s): Masaaki Hori, Kouhei Kamiya, Akifumi Hagiwara, Kazumasa Yokoyama, Issei Fukunaga, Katsuhiro Sano, Koji Kamagata, Katsutoshi Murata, Shohei Fujita, Christina Andica, Akihiko Wada, Julien Cohen-Adad, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition,
• [Presentation] Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging. (2021)
  • Author(s): Koji Kamagata, Christina Andica, Kaito Takabayashi, Yuya Saito, Wataru Uchida, Shohei Fujita, Toshiaki Akashi, Akihiko Wada, Kouhei Kamiya, Masaaki Hori, and Shigeki Aoki
  • Organizer: ISMRM 29th annual meeting and exhibition,
• [Presentation] Deep learning-based DWI Denoising method that suppressed the "instability" problem. (2021)
  • Author(s): Hayato Nozaki, Yasuhiko Tachibana, Yujiro Otsuka, Wataru Uchida, Yuya Saito, Koji Kamagata, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition,
• [Presentation] 機械学習によるUltrashort TE 4D MR Angiography の改善(電子ポスター) (2021)
  • Author(s): 和田昭彦、池之内穣、赤津敏哉、明石敏昭、佐野勝廣、藤田翔平、佐藤香菜子、鎌形康司、菊田潤子、富澤信夫、早川弥生、中西淳、青木茂樹
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] 深層学習モデルを用いた乳幼児脳MRIからの年齢推定 (2021)
  • Author(s): 和田 昭彦、斎藤 勇哉、藤田 翔平、加藤 伸平、池之内 穣、明石 敏昭、佐野 勝廣、 佐藤 香菜子、菊田 潤子、鎌形 康司、青木 茂樹
  • Organizer: 第50回神経放射線学会
• [Presentation] ALPS methodを用いた高血圧症における血管周囲腔方向の拡散能変化の検討. (2021)
  • Author(s): 菊田 潤子、鎌形 康司、高林 海斗、染谷 由希、田村 好史、河盛 隆造、 綿田 裕孝、田岡 俊昭、長縄 慎二、青木 茂樹
  • Organizer: 第50回神経放射線学会
• [Presentation] 小脳の区分と脳内のネットワークから脊髄小脳変性症の変性パターンの理解を深める (2021)
  • Author(s): 佐藤 香菜子、鎌形 康司、斎藤 勇哉、内田 航、菊田 潤子、池之内 穣、鈴木 通真、和田 昭彦、青木 茂樹
  • Organizer: 第57回日本医学放射線学会秋季臨床大会
• [Presentation] 限局性皮質形成異常の読影のポイント－手術予後に寄与するために－(The points of image reading of focal cortical dysplasia -For contributing to prognosis after surgery-) (2021)
  • Author(s): 佐藤香菜子、明石 敏昭、鎌形 康司 、菊田潤子、藤田 翔平、加藤 伸平、池之内 穣 、和田昭彦、青木茂樹
  • Organizer: 第50回日本神経放射線学会
• [Presentation] 3D MR Fingerprinting による脳構造毎の組織緩和時間と形態情報の同時解析に関する網羅的検討 (2021)
  • Author(s): 藤田翔平, Matteo Cencini, Guido Buonincontri, 竹井直行, 福永一星, 内田航, 萩原彰文, 鎌形康司, 阿部修, Michela Tosetti, 青木茂樹
  • Organizer: 第49回 日本磁気共鳴医学会大会
• [Presentation] DDEを用いた大脳皮質領域毎のμFA値計測の初期検討 (2021)
  • Author(s): 加藤 伸平、神谷 昂平、阿部 正裕、草原 博志、藤田 翔平、明石 敏昭、鎌形 康司、和田 昭彦、堀 正明、青木 茂樹
  • Organizer: 第50回神経放射線学会
• [Presentation] 脳膿瘍における短い拡散時間を用いた拡散時間依存性の検討 (2021)
  • Author(s): 前川 朋子、堀 正明、村田 勝俊、神谷 昂平、Andica Christina、藤田 翔平、萩原 彰文、鎌形 康司、和田 昭彦、青木 茂樹
  • Organizer: 第50回神経放射線学会
• [Presentation] 進行性核上性麻痺における free-water imaging による白質評価 (2020)
  • Author(s): 加藤亜結美、鎌形康司、Andica Christina、斎藤勇哉、萩原彰文、明石敏昭、和田昭彦、堀正明、藤井進也、青木茂樹.
  • Organizer: 第49回神経放射線学会
• [Presentation] U-Net を用いた生成脂肪抑制画像における有用性の検討 (2020)
  • Author(s): 加藤伸平、和田昭彦、斎藤勇哉、菊田潤子、藤本幸多朗、 藤田翔平、鎌形康司、鈴木通真、阿部修、青木茂樹
  • Organizer: 第49回神経放射線学会
• [Presentation] 深層学習 Unet を用いた脂肪信号抑制 MR 画像の試み ― 頭頸部領域への転移学習 (2020)
  • Author(s): 和田昭彦、加藤伸平、斎藤勇哉、藤本幸多朗、藤田翔平、明石敏昭、 鎌形康司、鈴木 通真、中西淳、青木茂樹
  • Organizer: 第49回神経放射線学会
• [Presentation] Coil 併用 Flow diverter stent 留置術後の内頸動脈瘤内 flow のUltrashort TE 4D MRA:2 症例における経験 (2020)
  • Author(s): 池之内穣、鈴木通真、髙野直、佐藤香菜子、明石敏昭、鎌形康司、和田昭彦、山本宗孝、大石英則、青木茂樹
  • Organizer: 第49回神経放射線学会
• [Presentation] What radiologists need to know about diffusion time. (2020)
  • Author(s): 前川朋子、堀正明、村田勝俊、神谷昂平、Christina Andica、萩原彰文、藤田翔平、鎌形康司、和田昭彦、青木茂樹
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] 大脳白質病変のGrade 分類に対するDeep learning の有用性 (2020)
  • Author(s): 菊田潤子、和田昭彦、加藤伸平、枝伸人、中嶋光、藤田哲郎、宇田川剛史、尾崎裕、青木茂樹
  • Organizer: 第49回日本神経放射線学会
• [Presentation] SuStaIn を用いた大脳皮質基底核症候群および進行性核上性麻痺における脳萎縮の時間的進行パターンの推定 (2020)
  • Author(s): 斎藤勇哉, 鎌形康司, アンディカ・クリスティナ, 内田航, 村田渉, 萩原彰文, 明石敏昭, 和田昭彦, 堀正明, 青木茂樹
  • Organizer: 第22回日本ヒト脳機能マッピング学会
• [Presentation] Free-water imagingを用いた自閉症スペクトラム障害に伴う大脳白質神経炎症の評価 (2020)
  • Author(s): 内田航、鎌形康司、桐野衛二、Christina Andica、斎藤勇哉、萩原彰文、明石敏昭、和田昭彦、藤田翔平、村田渉、堀正明、青木茂樹
  • Organizer: 第22回日本ヒト脳機能マッピング学会
• [Presentation] Radiomics with 3D MR fingerprinting: the influence of dictionary design on texture features and a way to mitigate it (2020)
  • Author(s): Shohei Fujita, Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Shigeru Kiryu, Issei Fukunaga, Shimpei Kato, Akifumi Hagiwara, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki.
  • Organizer: The 48th Annual Meeting of the JSMRM
• [Presentation] 転移性脳腫瘍検出率のGd造影剤投与後経過時間による変化 (2020)
  • Author(s): 神谷昂平、入江隆介、工藤興亮、五味達哉、尾﨑裕、野崎美和子、京極伸介、南学、石口恒男、阪原晴海、村上卓道、鳴海善文、粟井和夫、原田雅史、大久保敏之、岡田進、青木茂樹.
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] PyramidNet深層機械学習モデルを用いた頚部リンパ節の検出 (2020)
  • Author(s): 加藤伸平、和田昭彦、斎藤勇哉、藤田翔平 、池之内穣、早川弥生、佐藤香菜子、富澤信夫、明石敏昭、天野真紀、鎌形康司、隈丸加奈子、佐野勝廣、中西淳、阿部修、青木茂樹
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] White matter integrity as a mediator in the relationship between polyunsaturated fatty acids and cognition in the elderly. (2020)
  • Author(s): Koji Kamagata, Kazunori Shimada, Hideyoshi Kaga, Yuki Someya, Christina Andica, Yuya Saito, Toshiaki Akashi, Akihiko Wada, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Hiroyuki Daida, Shigeki Aoki
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] Microscopic fractional anisotropy measurements from double diffusion encoding for human brain tumor diagnosis. (2020)
  • Author(s): Masaaki Hori, Masanori Ozaki, Hiroshi Kusahara, Masahiro Abe, Shuji Sato, Seiko Shimizu, Kouhei Kamiya, Toshiaki Akashi, Koji Kamagata, Shigeki Aoki.
  • Organizer: ISMRM 28th annual meeting
• [Presentation] Differentiation of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders by Convolutional Neural Network. (2020)
  • Author(s): Hagiwara A, Otsuka Y, Andica C, Kato S, Yokoyama K, Hori M, Fujita S, Kamagata K, Irie R, Koshino S, Maekawa T, Akashi T, Wada A, Kumamaru K, Haruyama T, Murata S, Hattori N, Aoki S.
  • Organizer: International Society for Magnetic Resonance in Medicine Virtual Conference & Exhibition.
• [Book] Diffusion Weighted MR Imaging of the Brain, Head and Neck, and Spine (2020)
  • Author(s): Takayuki Obata, Jeff Kershaw, Akifumi Hagiwara, Shigeki Aoki
  • Total Pages: ー
  • Publisher: Springer
• [Book] 「筋萎縮性側索硬化症」、「Huntington病」. よく分かる脳MRI 第4版 (2020)
  • Author(s): 編著：青木茂樹、相田典子、井田正博、大場洋、佐藤香菜子(分担執筆者)
  • Total Pages: ー
  • Publisher: 学研メディカル秀潤社
• [Book] よくわかる脳MRI 改訂第4版（画像診断別冊 KEY BOOKシリーズ）多発性硬化症：治療後の変化. (2020)
  • Author(s): 青木茂樹、相田典子、越野沙織、 井田正博、大場洋(著, 編集)
  • Total Pages: ー
  • Publisher: 学研メディカル秀潤社
• [Book] Annual Review神経 (2020)
  • Author(s): 鎌形康司、アンディカ・クリスティナ、青木茂樹
  • Total Pages: ー
  • Publisher: 中外医学社
• [Book] INNERVISION (2020)
  • Author(s): 明石敏昭、青木茂樹
  • Total Pages: ー
  • Publisher: 株式会社インナービジョン
• [Remarks] doi: 10.1093/cercor/bhac096.
• [Remarks] doi: 10.1016/j.neuroimage.2022.119176.
• [Remarks] Front Neurol. 2022 Feb 25;13:814768.