2009 Fiscal Year Final Research Report

Non-verbal executive function in the left frontal lobe in patients with brain tumor resection

Research Project

Project/Area Number	19300093
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Cognitive science
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	KUMADA Takatsune National Institute of Advanced Industrial Science and Technology, 人間福祉医工学研究部門, 研究グループ長 (70221942)
Co-Investigator(Kenkyū-buntansha)	MYRAGAKI Yoshihiro 東京女子医科大学, 脳神経外科, 准教授 (70210028) MARUYAMA Takashi 東京女子医科大学, 脳神経外科, 講師 (40301543)
Project Period (FY)	2007 – 2009
Keywords	前頭葉 / 注意 / 遂行機能
Research Abstract	We examined task-switching functions of frontal regions in patients with brain tumor using intracranial electrodes and voxel-based lesion symptom mapping (VLSM) techniques. In Study 1, EEG was recorded via electrodes planted in the left frontal lobe of a patient. An electrode in the left inferior frontal sulcus recorded negative potentials to the onset of a cue.In Study 2, 29 patients performed a cued visual search task. Their performance and resected brain areas were subjected to a VLSM procedure, showed that the left middle frontal region involved in configuration of task-set, whereas the left inferior frontal regions involved in maintenance of it. These results revealed that left frontal regions have different functions related to task-switching.

(5 results)