Life time control of biodegradable composites for scaffolds in bone tissue engineering

2009 Fiscal Year Final Research Report

• Project/Area Number: 19360050
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Materials/Mechanics of materials
• Research Institution: Kyoto University
• Principal Investigator: HOJO Masaki Kyoto University, 工学研究科, 教授 (70252492)
• Co-Investigator(Kenkyū-buntansha): ADACHI Taiji 京都大学, 工学研究科, 准教授 (40243323)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Mototsugu 金沢工業大学, 工学部, 講師 (30346085) ; NISHINO Takashi 神戸大学, 工学部, 教授 (40180624)
• Project Period (FY): 2007 – 2009
• Keywords: 材料設計 / プロセス / 物性 / 評価 / 複合材料 / 生分解性樹脂 / 組織再生工学 / ハイドロキシアパタイト / ポリ乳酸 / スカフォールド / 骨リモデリング

Research Abstract

Hydroxyapatite (HAp)/poly-L-lactic acid (PLLA) composite material was developed for the development of biodegradable three-dimensional porous scaffolds for bone tissue engineering. Both particle and fiber type HAp was compared Interface control was also tried for HAp particle. These mesoscopic factors had great influence on the deformation and fracture behavior of HAp/PLLA composites. Moreover, hydrolysis of this composite material was strongly affected by the surface treatment of HAp particles.

Research Products

• [Journal Article] Mode I fatigue delamination of Zanchor-reinforced CF/epoxy laminates. (2010)
  • Author(s): Hojo, M., Nakashima, K., Kusaka, T., Tanaka, M., Adachi, T., Fukuoka T., Ishibashi, M.
  • Journal Title: International Journal of Fatigue Vol.32 Pages: 37-45
  • Peer Reviewed
• [Journal Article] Effect of fiber array irregularities on microscopic interfacial normal stress states of transversely loaded UD-CFRP from viewpoint of failure initiation (2009)
  • Author(s): Hojo, M., Mizuno, M., Hobbiebrunken, T., Adachi, T., Tanaka, M., Ha, S.K.
  • Journal Title: Composites Science and Technology 69(11-12) Pages: 1726-1734
  • Peer Reviewed
• [Journal Article] Damage characterization of fibre metal laminates under interlaminar shear load (2009)
  • Author(s): Hinz, S., Omoori, T., Hojo, M., Schulte, K.
  • Journal Title: Composites: Part A Vol.40 Pages: 925-931
  • Peer Reviewed
• [Journal Article] Fluid pressure response in poroelastic materials subjected to cyclic loading (2009)
  • Author(s): Kameo, Y., Adachi, T., Hojo, M.
  • Journal Title: Journal of the Mechanics and Physics of Solids Vol.57 Pages: 1815-1827
  • Peer Reviewed
• [Journal Article] Strain field in actin filament network in lamellipodia of migrating cells: Implication for network reorganization (2009)
  • Author(s): Adachi, T., Okeyo, K.O., Shitagawa, Y., Hojo, M.
  • Journal Title: Journal of Biomechanics Vol.42 Pages: 297-302
  • Peer Reviewed
• [Journal Article] Computer simulation of trabecular remodeling in human proximal femur using large-scale voxel FE models: Approach to understanding Wolff's law (2009)
  • Author(s): Tsubota, K., Suzuki, Y., Yamada, T., Hojo, M., Makinouchi, A., Adachi, T.
  • Journal Title: Journal of Biomechanics Vol.42,Issue8 Pages: 1088-1094
  • Peer Reviewed
• [Journal Article] Coarse-grained Modeling and Simulation of Actin Filament Behavior Based on Brownian Dynamics Method (2009)
  • Author(s): Shimada, Y., Adachi, T., Inoue, Y., Hojo, M.
  • Journal Title: Molecular and Cellular Biomechanics 6(3) Pages: 161-174
  • Peer Reviewed
• [Journal Article] Wall boundary model for primitive chain network simulations (2009)
  • Author(s): Okuda, S., Inoue, Y., Masubuchi, Y., Uneyama, T., Hojo, M.
  • Journal Title: The Journal of Chemical Physics Vol.130 Pages: 214907-1-7
  • Peer Reviewed
• [Journal Article] In-situ observation of interfacial crack propagation in GF/epoxy model composite using bifiber specimens in mode I and mode II loading (2008)
  • Author(s): Hojo, M., Matsushita, Y., Tanaka, M., Adachi, T.
  • Journal Title: Composites Science and Technology Vol.68 Pages: 2678-2689
  • Peer Reviewed
• [Journal Article] Influence of non-uniform fiber arrangement on microscopic stress and failure initiation in thermally and transversely loaded CF/epoxy laminated composites (2008)
  • Author(s): Hobbiebrunken, T., Hojo, M., Jin, K.K., Ha, S.K.
  • Journal Title: Composites Science and Technology Vol.68 Pages: 3107-3113
  • Peer Reviewed
• [Journal Article] In-situ observation of interfacial debonding process induced by matrix crack propagation in two-dimensional unidirectional model composites (2008)
  • Author(s): Tanaka, M., Kawaguchi, T., Hojo, M., Ochiai, S., Nakanishi, Y.
  • Journal Title: Composite Interfaces 15(1) Pages: 75-94
  • Peer Reviewed
• [Journal Article] Zanchor強化CFRP積層材のモードI層間き裂進展挙動の実験的評価 (2008)
  • Author(s): 日下貴之, 渡辺圭子, 北條正樹, 福岡俊康, 石橋正康
  • Journal Title: 日本複合材料学会誌 34(3) Pages: 102-108
  • Peer Reviewed
• [Journal Article] Zanchor強化CFRP積層材のモードII層間き裂進展挙動の実験的評価 (2008)
  • Author(s): 渡辺圭子, 日下貴之, 北條正樹, 福岡俊康, 石橋正康
  • Journal Title: 日本複合材料学会誌 34(6) Pages: 226-232
  • Peer Reviewed
• [Journal Article] Transient response of fluid pressure in a poroelasitic material under uniaxial cyclic loading (2008)
  • Author(s): Kameo, Y., Adachi, T., Hojo, M.
  • Journal Title: Journal of the Mechanics and Physics of Solids 56(5) Pages: 1794-1805
  • Peer Reviewed
• [Journal Article] Simultaneous Observation of Calcium Signaling Response and Membrane Deformation due to Localized Mechanical Stimulus in Single Osteoblast-like Cells (2008)
  • Author(s): Adachi, T., Sato, K., Higashi, N., Tomita, Y., Hojo, M.
  • Journal Title: Journal of the Mechanical Behavior of Biomedical Materials 1(1) Pages: 43-50
  • Peer Reviewed
• [Journal Article] 3次元編み構造からなる生分解性複合材料スカフォールドの力学的特性と生分解性特性の評価 (2008)
  • Author(s): 日和千秋, 横田久美子, 中井善一, 田中信生, 井上俊之, 安達泰治, 北條正樹, 馬場俊介
  • Journal Title: 材料 57(9) Pages: 868-874
  • Peer Reviewed
• [Journal Article] 編物複合材料の再生医療用スカフォールドへの適用(I)-生分解性樹脂による編物複合材料の開発- (2008)
  • Author(s): 田中信生, 日和千秋, 井元俊之, 安達泰治, 北條正樹, 馬場俊輔
  • Journal Title: 材料システム 26巻 Pages: 79-88
  • Peer Reviewed
• [Journal Article] 編物複合材料の再生医療用スカフォールドへの適用(II)-マウス骨芽細胞様細胞による骨組織形成過程- (2008)
  • Author(s): 日和千秋, 沖添晃政, 中井善一, 田中信生, 安達泰治, 北條正樹, 馬場俊輔
  • Journal Title: 材料システム 26巻 Pages: 89-95
  • Peer Reviewed
• [Journal Article] Experimental determination of the true epoxy resin strength using micro-scaled specimens (2007)
  • Author(s): Hobbiebrunken, T., Fiedler, B., Hojo, M., Tanaka, M.
  • Journal Title: Composites Part A Vol.38 Pages: 814-818
  • Peer Reviewed
• [Journal Article] Suppression of interfacial crack for foam core sandwich panel with crack arrester (2007)
  • Author(s): Hirose, Y., Hojo, M., Fujiyoshi, A., Matsubara, G.
  • Journal Title: Advanced Composite Materials 16(1) Pages: 11-30
  • Peer Reviewed
• [Journal Article] Measurement of local strain on cell membrane at initiation point of calcium signaling response to applied mechanical stimulus in osteoblastic cell (2007)
  • Author(s): Sato, K., Adachi, T., Ueda, D., Hojo, M., Tomita, Y.
  • Journal Title: Journal of Biomechanics Vol.40.Issue6 Pages: 1246-55
  • Peer Reviewed
• [Journal Article] ヒト大腿骨近位部海綿骨の骨梁リモデリングシミュレーション (2007)
  • Author(s): 安達泰治, 鈴木優介, 坪田健一, 北條正樹
  • Journal Title: 日本骨形態計測学会雑誌 17巻 Pages: 15-20
  • Peer Reviewed
• [Presentation] Mechanical properties of bone-porous scaffold structure in bone regeneration predicted by 3D computational simulation (2009)
  • Author(s): Hojo, M., Adachi, T.
  • Organizer: Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry (Zhejiang Sci-Tech University) and JCOM Joint Workshop on Composite Materials
  • Place of Presentation: Zhejian, China
  • Year and Date: 20091005-20091006
• [Presentation] Change in Deformation/Fracture Behavior of Interface- Controlled HAp/PLLA Composites by ydrolysis (2009)
  • Author(s): Tanaka, M., Tanaka, H., Hojo, M., Adachi, T., Sugihara, M., Kotera, M., Nishino, T.
  • Organizer: Proceedings of 17th International Conference on Composite Materials
  • Place of Presentation: Edinburg
  • Year and Date: 20090727-20090731
• [Presentation] Damage Initiation under Transverse Loading of UD-CFRP with Random Fiber Arrangement (2009)
  • Author(s): Hojo, M., Mizuno, M., Hobbiebrunken, T., Adachi, T., , Jin, K.K.
  • Organizer: Fourth China-Europe Symposium on Processing and Properties of Reinforced Polymers p. 17
  • Place of Presentation: Guilin, China
  • Year and Date: 20090608-20090612
• [Presentation] Transient and Steady-State Behaviors of Fluid Pressure in Poroelastic Materials under Cyclic Axial and Bending Loading (2009)
  • Author(s): Kameo, Y., Adachi, T., Hojo, M.
  • Organizer: The Fourth Biot Conference on Poromechanics
  • Place of Presentation: New York
  • Year and Date: 20090608-20090610
• [Presentation] Mechanical Properties of Bone-Porous Scaffold Structure in Bone Regeneration Predicted by 3D Computational Simulation (2009)
  • Author(s): Hojo, M., Adachi, T., Osako, Y., Tanaka, M.
  • Organizer: The 11th Japan International SAMPE Symposium and Exhibition
  • Place of Presentation: Tokyo
  • Year and Date: 2009-11-26
• [Remarks]
  • URL: http://ams.me.kyoto-u.ac.jp/