2009 Fiscal Year Final Research Report
Development of F-18 fluorodeoxymannose (FDM) as a PET probe for cancer imaging
| Project/Area Number |
19390312
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUDA Hiroshi Tohoku University, 加齢医学研究所, 教授 (30125645)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Ren 東北大学, サイクロトロンラジオアイソトープセンター, 教授 (60143038)
YOSHIOKA Takashi 山形大学, 医学部, 教授 (90271981)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUMOTO Shozo 東北大学, 大学院・医学系研究科, 講師 (00375198)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 画像診断学(含放射線診断学、核医学) |
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| Research Abstract |
We attempted to develop a method for radio-synthesis of ^<18>F-fluorodeoxymannose (^<18>F-FDM) by nucleofilic substituted reaction. We synthesized 3 precursors for ^<18>F-FDM radio-synthesis and ^<18>F-FDM was successfully synthesized using precursor 3 with high radiochemical yield (43-67%) and purity (94-98%). Bio-distribution and imaging studies of tumor bearing rat revealed high tumor uptake, relatively low uptake in the brain and rapid clearance from the kidney and blood. No acute toxicity was found in mice administered with 0.1および1.0mg/kg of cold FDM.
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