2009 Fiscal Year Final Research Report
Functional analysis of newly acquired genes that directed the evolution of chordates.
| Project/Area Number |
19570220
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Evolutionary biology
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
FUJIWARA Shigeki Kochi University, 教育研究部自然科学系, 教授 (40229068)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | レチノイン酸 / 発生・分化 / 脊索動物 / 進化 / 遺伝子 |
|---|
| Research Abstract |
I analyzed the function of genes that were involved in the establishment of the chordate-specific body plan. Retinoic acid has been thought to function only in vertebrate embryos. In the present study, I demonstrated that retinoic acid contributed to organogenesis in the ascidian embryo, through the activation of the Hox1 gene. I also demonstrated that the growth factor, Nodal, was required for morphogenesis of the dorsal neural tube, which was a chordate-specific feature. The transcription factor, Cdx, was revealed to mediatethe Nodal signal and regulates neural tube formation.
|
-
-
-
-
-
-
-
-
-
[Journal Article] Gene expresion profile during the life cycle of the urochordate Ciona intestinalis2007
Author(s)
Azumi, K., Sabau, S.V., Fujie, M., Usami, T., Koyanagi, R., Kawashima, T., Fujiwara, S., Ogasawara, M., Satake, M., Nonaka, M., Wang, H-G., Satou, Y., Satoh, N
-
Journal Title
Dev. Biol vol.308
Pages: 572-582
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
