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2009 Fiscal Year Final Research Report

Preparations of novel selenium- or tellurium-containing heterocycles and their functionalities

Research Project

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Project/Area Number 19590022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHokuriku University

Principal Investigator

SASHIDA Haruki  Hokuriku University, 薬学部, 教授 (70102746)

Co-Investigator(Kenkyū-buntansha) SUZUKI Hirokazu   (70257484)
Project Period (FY) 2007 – 2009
Keywordsヘテロ環化学
Research Abstract

Preparations of novel several selenium- or tellurium- containing heterocycles by the intramolecular cyclization of the selenols, tellurols and related compounds to a triple bond are achieved. The structures, reactivities and functionalities involving the bioactivities of the obtained products were also examined towards the medicinal chemistry.

  • Research Products

    (34 results)

All 2010 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (20 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A facile and practical solvent-free one-pot synthesis of (Z)-4-methylidene-3-selenaquinoline derivatives from o-ethynylanilines and isoselenocyanates2010

    • Author(s)
      Haruki Sashida, Chao Pan, Mamoru Kaname, Mao Minoura
    • Journal Title

      Synthesis (in press)

    • Peer Reviewed
  • [Journal Article] A straightforward double intramolecular cyclization of dibenzyl dichalcogenols into a triple bond2010

    • Author(s)
      Haruki Sashida, Mamoru Kaname, Akemi Nakayama, Hirokazu Suzuki, Mao Minoura
    • Journal Title

      Tetrahedron 66

      Pages: 5149-5157

    • Peer Reviewed
  • [Journal Article] Tin-tellurium exchange reaction in tin-containing heterocycles: A new entry for the preparation of tellurium heterocycles2010

    • Author(s)
      Haruki Sashida, Mamoru Kaname, Kazuo Ohyanagi
    • Journal Title

      Heterocycles 82(in press)

    • Peer Reviewed
  • [Journal Article] Novel oxidative ring opening reaction of isotellurochromones to bis(o-formylstylyl) ditellurides2010

    • Author(s)
      Haruki Sashida, Hirohito Satoh, Kazuo Ohyanagi, Mamoru Kaname
    • Journal Title

      Molecules 15

      Pages: 1466-1472

    • Peer Reviewed
  • [Journal Article] 2-Substituted isotellurochromenium salt derivatives: preparations, structures and spectroscopic properties2010

    • Author(s)
      Haruki Sashida, Shoko Nakabayashi, Mamoru Kaname, Mao Minoura
    • Journal Title

      Heterocycles 80

      Pages: 1339-1352

    • Peer Reviewed
  • [Journal Article] 1-ベンゾテルロピリリウム塩の化学:合成, 構造, 反応2009

    • Author(s)
      指田春喜, 箕浦真生
    • Journal Title

      有機合成化学協会誌 67

      Pages: 714-723

    • Peer Reviewed
  • [Journal Article] Ruthenium tetroxide oxidation of N, N'-diacyl hexahydropyridazines2009

    • Author(s)
      Mamoru Kaname, Shigeyuki Yoshifuji, Haruki Sashida
    • Journal Title

      Heterocycles 79

      Pages: 647-658

    • Peer Reviewed
  • [Journal Article] An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives2009

    • Author(s)
      Mamoru Kaname, Masae Yamada, Shigeyuki Yoshifuji, Haruki Sashida
    • Journal Title

      Chem. Pharm. Bull. 57

      Pages: 49-54

    • Peer Reviewed
  • [Journal Article] An efficient one-pot synthetic method for selenium-containing medium-sized α,β-unsaturated cyclic ketones2008

    • Author(s)
      Haruki Sashida, Akemi Nakayama, Mamoru Kaname
    • Journal Title

      Synthesis

      Pages: 3229-3236

    • Peer Reviewed
  • [Journal Article] An efficient transformation of cyclic ene-carbamates into ω-(N-formylamino)carboxylic acids by ruthenium tetroxide oxidation2008

    • Author(s)
      Mamoru Kaname, Shigeyuki Yoshifuji, Haruki Sashida
    • Journal Title

      Chem. Pharm. Bull. 56

      Pages: 1310-1313

    • Peer Reviewed
  • [Journal Article] Ruthenium tetroxide oxidation of α-(N-acyl)aminophosphonic acid diesters2008

    • Author(s)
      Mamoru Kaname, Hironori Mashige, Shigeyuki Yoshifuji, Haruki Sashida
    • Journal Title

      Heterocycles 76

      Pages: 429-438

    • Peer Reviewed
  • [Journal Article] Ruthenium tetroxide oxidation of cyclic N-acylamines by a single layer method: formation of ω-amino acids2008

    • Author(s)
      Mamoru Kaname, Shigeyuki Yoshifuji, Haruki Sashida
    • Journal Title

      Tetrahedron Lett. 49

      Pages: 2786-2788

    • Peer Reviewed
  • [Journal Article] 1-Benzoselenopyrylium salts and 1-benzotelluropyrylium salts: Preparations, structures and reactions2007

    • Author(s)
      Haruki Sashida
    • Journal Title

      Mini Reviews in Organic Chemistry 4

      Pages: 105-114

    • Peer Reviewed
  • [Presentation] 酸触媒によるσ-エチニルフェノール類とイソセレノシアネートとの付加・環化反応2010

    • Author(s)
      要衛, 潘超, 指田春喜
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      20100328-20100330
  • [Presentation] イソテルロクメニウム塩関連化合物:合成, 構造, 性質2009

    • Author(s)
      要衛, 中林祥子, 指田春喜
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      20091116-20091117
  • [Presentation] σ-エチニルアニリンおよびフェノール類とイソセレノシアネートとの付加・環化反応2009

    • Author(s)
      要衛, 潘超, 山田理恵, 村山次哉, 指田春喜
    • Organizer
      第39回複素環化学討論会
    • Place of Presentation
      柏
    • Year and Date
      20091014-20091016
  • [Presentation] Double intramolecular 5-exo and 6-endo cyclization of dibenzyl ditellurols into triple bond2009

    • Author(s)
      Haruki Sashida, Mamoru Kaname, Akemi Nakayama, Mao Minoura
    • Organizer
      13th Blue Danube Symposium on Heterocyclic Chemistry
    • Place of Presentation
      Bled, Slovenia
    • Year and Date
      20090920-20090923
  • [Presentation] Selenium-containing heterocycles 2. A straightforward double intramolecular cyclization of dibenzyl diselenols into an ethynyl group2009

    • Author(s)
      Haruki Sashida, Akemi Nakayama, Mamoru Kaname
    • Organizer
      22nd International Congress on Heterocyclic Chemistry
    • Place of Presentation
      St. John's, Canada
    • Year and Date
      20090802-20090807
  • [Presentation] Selenium-containing heterocycles 1. One-pot synthesis of (Z)-1-methylidenebenzo[c]selenophenes from o-ethynylbomobenzenes and isoselenocyanate2009

    • Author(s)
      Mamoru Kaname, Haruki Sashida
    • Organizer
      22nd International Congress on Heterocyclic Chemistry
    • Place of Presentation
      St. John's, Canada
    • Year and Date
      20090802-20090807
  • [Presentation] セレノール類の三重結合への環化反応(1):ヨードサイクリゼーションによるベンゾ[c]セレノフェン誘導体の合成2009

    • Author(s)
      要衛, 指田春喜
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090326-20090328
  • [Presentation] セレノール類の三重結合への環化反応(2):マイクロウェーブ照射による3-セレナキノリン類の効率的合成2009

    • Author(s)
      要衛, 潘超, 指田春喜
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090326-20090328
  • [Presentation] 三重結合を有するアルコールおよびフェノール類とイソセレノシアネート類との付加・環化反応2009

    • Author(s)
      要衛, 潘超, 指田春喜
    • Organizer
      北陸支部120回例会
    • Place of Presentation
      金沢
    • Year and Date
      2009-07-11
  • [Presentation] 三重結合を有する求核剤とイソセレノシアネートとの反応による含セレン複素環合成2008

    • Author(s)
      要衛, 潘超, 指田春喜
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Year and Date
      20081121-20081123
  • [Presentation] 各種σ-エチニルベンジルカルコゲノール類の環化反応2008

    • Author(s)
      要衛, 中山明美, 指田春喜
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      20081104-20081105
  • [Presentation] A new one-pot synthetic method for selenium-containing medium-sized α,β-unsaturated cyclic ketones by the ring-expansion reaction of selenolavtones with ethynyllithium2008

    • Author(s)
      Haruki Sashida, Akemi Nakayama, Mamoru Kaname
    • Organizer
      23th European colloqium on heterocyclic chemistry
    • Place of Presentation
      Antwerp, Belgium
    • Year and Date
      20080909-20080913
  • [Presentation] 分子内三重結合へのジカルコゲノールの位置選択的タンデム環化反応2008

    • Author(s)
      要衛, 中山明美, 指田春喜
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      20080326-20080328
  • [Presentation] o-エチニルアニリン類とイソセレノシアネートによる3-セレナキノリン誘導体の合成2008

    • Author(s)
      要衛, 潘超, 指田春喜
    • Organizer
      日本薬学会北陸支部第119回例会
    • Place of Presentation
      金沢
    • Year and Date
      2008-11-09
  • [Presentation] ビス(σ-エチニルベンジルカルコゲノール)関連化合物の環化反応2008

    • Author(s)
      要衛, 中山明美, 指田春喜
    • Organizer
      日本薬学会北陸支部第119回例会
    • Place of Presentation
      金沢
    • Year and Date
      2008-11-09
  • [Presentation] σ-エチニルフェニルリチウムとイソセレノシアネートによる含セレン複素環合成2008

    • Author(s)
      要衛, 指田春喜
    • Organizer
      日本薬学会北陸支部第118回例会
    • Place of Presentation
      富山
    • Year and Date
      2008-07-05
  • [Presentation] 四酸化ルテニウム酸化(単層法)を用いる環状N-アシルアミン類からω-アミノ酸への変換2007

    • Author(s)
      要衛, 吉藤茂行, 指田春喜
    • Organizer
      第33回反応と合成のシンポシンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      20071105-20071106
  • [Presentation] セレノラクトン類のエチニルリチウムによる環拡大反応:含セレンα,β-不飽和中員環ケトンの生成2007

    • Author(s)
      要衛, 中山明美, 指田春喜
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Year and Date
      20071017-20071019
  • [Presentation] [4+2^+] Polar cycloaddition of 2-benzotelluropyrylium salts and reaction of the cycloadducts with nucleophiles2007

    • Author(s)
      Haruki Sashida, Kazuo Ohyanagi
    • Organizer
      10th International Conference on the Chemistry of Selenium and Tellurium
    • Place of Presentation
      Lodz, Poland
    • Year and Date
      20070622-20070627
  • [Presentation] Introduction of carbon functional groups into C-1 position of 2-benzotelluropyrylium salts2007

    • Author(s)
      Haruki Sashida, Kazuo Ohyanagi
    • Organizer
      10th International Conference on Pure and Applied Heterocyclic Chemistry
    • Place of Presentation
      Luxor, Egypt
    • Year and Date
      20070217-20070220
  • [Patent(Industrial Property Rights)] 含セレン複素環化合物及びその用途2009

    • Inventor(s)
      指田春喜, 要衛
    • Industrial Property Rights Holder
      指田春喜, 要衛
    • Industrial Property Number
      公開特許・2009-106140
    • Filing Date
      2009-04-21
    • Acquisition Date
      2009-04-21

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Published: 2011-06-18   Modified: 2016-04-21  

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