Genome diversities in genes for NK cell function and their clinical and biological roles.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19590330
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NARUSE Taeko Tokyo Medical and Dental University, 難治疾患研究所, 特任教員 (80422476)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
• Project Period (FY): 2007 – 2009
• Keywords: 分子遺伝学 / NKレセプター / ゲノム多様性 / リガンド多型 / 遺伝子多型

Research Abstract

We have investigated genome diversity of ULBP/RAET1 gene family and found that ULBP4 gene was the most polymorphic with 8 single nucleotide polymorphisms in exons and an insertion/deletion and (GT)n repeat polymorphisms in the promoter region. In addition, specific allele of KIR-3DL1 was associated with the resistance to HIV/AIDS. These observations suggested that allelic diversities of NK receptors and ligands lead to the functional difference of NK cells.

Research Products

• [Journal Article] Leelayuwat. Polymorphisms of NKG2D ligands : diverse RAET1/ULBP genes in northeastern Thais (2009)
  • Author(s): Romphruk AV, Romphruk A, Naruse TK, Raroengjai S, Puapairoj C, Inoko H
  • Journal Title: Immunogenetics 61 Pages: 611-617
  • Peer Reviewed
• [Journal Article] Complex divergence at a microsatellite marker C1_2_5 in lineage of HLA-Cw/-B haplotype (2009)
  • Author(s): Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse T, Kimura A.
  • Journal Title: J Hum Genet. 54 Pages: 224-229
  • Peer Reviewed
• [Journal Article] rans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus) (2009)
  • Author(s): Kikkawa EF, Tsuda TT, Sumiyama D, Naruse TK, Fukuda M, Kurita M, Wilson RP, LeMaho Y, Miller GD, Tsuda M, Murata K, Kulski JK, Inoko H.
  • Journal Title: Immunogenetics 61 Pages: 341-352
  • Peer Reviewed
• [Journal Article] HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis (2009)
  • Author(s): Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A
  • Journal Title: J Hum Genet 54(2) Pages: 108-114
  • Peer Reviewed
• [Journal Article] Re-evaluation of heterogeneity in HLA-B*510101 associated with Behcet's disease (2008)
  • Author(s): Takemoto Y, Naruse TK, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Shams H, Davatchi F, Inoko H, Ohno S, Kimura A
  • Journal Title: Tissue Antigens 72 Pages: 347-353
  • Peer Reviewed
• [Journal Article] HLA-DP beta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy (2008)
  • Author(s): Shichi D, Matsumori A, Naruse TK, Inoko H, Kimura A
  • Journal Title: Int J Immunogenet 35 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia (2007)
  • Author(s): Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya J, Terunuma H, Kimura A
  • Journal Title: Immunogenetics 59 Pages: 793-798
  • Peer Reviewed
• [Journal Article] Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease (2007)
  • Author(s): Chen Z, Takahashi M, Naruse T, Nakajima T, Chen Yi-Wen, Inoue Y, Ishikawa Isao, Iwai T, Kimura A.
  • Journal Title: Hum Genet 122 Pages: 367-372
  • Peer Reviewed
• [Presentation] MHC class I diversity and efficacy of SIV vaccines (2009)
  • Author(s): Naruse T, Yamashita T, Mori K, Chen Z, Saito Y, Matano T, Kimura A.
  • Organizer: 33rd annual conference of the Australasian and south east Asian tissue typing association (ASEATTA 2009)
  • Place of Presentation: IDSA (Delhi, India)
  • Year and Date: 2009-11-13
• [Presentation] MHC class I diversity and efficacy of vaccination against SIV (simian immunodeficiency virus) in rhesus macaque (2009)
  • Author(s): Naruse T, Yamashita T, Mori K, Chen Z, Saito Y, Matano T, Kimura A.
  • Organizer: 12th cardiovascular genomics and atherosclerosis symposium
  • Place of Presentation: Severance Hospital (Seoul, Korea)
  • Year and Date: 2009-10-17
• [Presentation] HIV感染後AIDS発症の個体差とKIR遺伝子多型、HLA遺伝子多型との関連 (2009)
  • Author(s): 小西真紀子, 柳田梨沙, 成瀬妙子, 中島敏晶, 照沼裕, 三間屋純一, 木村彰方
  • Organizer: 第18回日本組織適合性学会大会
  • Place of Presentation: 名古屋国際会議場 (愛知県)
  • Year and Date: 2009-09-26
• [Presentation] ヒトおよびアカゲザルNKG2Dレセプター関連遺伝子群の多型解析 (2009)
  • Author(s): 成瀬妙子, 奥田裕紀子, 俣野哲朗, 森一泰, 保冨康宏, 宮澤正顕, 木村彰方
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 高輪プリンスホテル (東京都)
  • Year and Date: 2009-09-25
• [Presentation] Immunogenetics of MHC in susceptibility to infectious disease (2008)
  • Author(s): Naruse T.
  • Organizer: 11^<th> cardiovascular genomics and artherosclerosis symposium
  • Place of Presentation: Samsung Seoul Hospital (Seoul, Korea)
  • Year and Date: 2008-11-01
• [Presentation] ヒトおよびアカゲザルにおけるNKG2Dレセプター関連遺伝子群の多型解析 (2008)
  • Author(s): 成瀬妙子, 柳田梨紗, 俣野哲朗, 森一泰, 保富康宏, 宮澤正顕, 木村彰方
  • Organizer: 第17回日本組織適合性学会大会
  • Place of Presentation: 大阪国際会議場 (大阪府)
  • Year and Date: 2008-09-21
• [Presentation] HIV感染後AIDS発症の個体差とKIR遺伝子多型との関連 (2008)
  • Author(s): 柳田梨沙, 成瀬妙子, 中島敏晶, 照沼裕, 三間屋純一, 木村彰方
  • Organizer: 第17回日本組織適合性学会大会
  • Place of Presentation: 大阪国際会議場 (大阪府)
  • Year and Date: 2008-09-21
• [Presentation] Polymorphisms in the loci for NKG2 receptors and their ligands in HIV/AIDS (2007)
  • Author(s): Naruse T, Kimura A, Terunuma H, Mimaya J.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: グランドプリンス新高輪 (東京都)
  • Year and Date: 2007-11-20
• [Presentation] ヒトおよび実験動物サルにおけるNKG2Dレセプター関連遺伝子多型性解析 (2007)
  • Author(s): 成瀬妙子, 俣野哲朗, 森一泰, 本多三男, 保富康宏, 宮澤正顕, 木村彰方
  • Organizer: 日本人類遺伝学会第52回大会
  • Place of Presentation: 京王プラザホテル (東京都)
  • Year and Date: 2007-09-13
• [Presentation] Polymorphisms in the loci for NKG2 receptors and their ligands in HIV/AIDS (2007)
  • Author(s): Naruse T, Terunuma H, Mimaya J, Kimura A.
  • Organizer: 第7回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台 (兵庫県)
  • Year and Date: 2007-09-01