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2008 Fiscal Year Final Research Report

RNA interference-based therapeutic molecular targeting strategy using nano drug delivery systems to eradicate malignant melanoma

Research Project

  • PDF
Project/Area Number 19591323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SABURO Kishimoto  Kyoto Prefectural University of Medicine, 医学研究科, 教授 (90079913)

Project Period (FY) 2007 – 2008
Keywords悪性黒色腫 / 分子標的治療 / RNAインタフェレンス / サイトカイン / 免疫療法
Research Abstract

我々は最近、メラノーマに発現するbHLH転写因子、MITFをRNAiにて抑制すると、メラノーマがアポトーシスに陥り、増殖が阻止できることを見出した。本研究では、さらなる発展として、IL-12免疫遺伝子療法との併用により、それらの相乗作用によるより強力なメラノーマの抑制に成功した。さらに、ナノDDSによるsiRNA導入を試みるとともに、膜透過性ペプチドによるMITF特異的分子標的療法の試みを行った。

  • Research Products

    (6 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] Immunoregulatory T cells in the peripheral blood of melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination2009

    • Author(s)
      Nakai N, Katoh N, Kitagawa T, Ueda E, Takenaka H, Kishimoto S
    • Journal Title

      J Dermatol Sci 54 (1)

      Pages: 31-37

    • Peer Reviewed
  • [Journal Article] Immunohistological analysis of peptide-induced delayed-type hypersensitivity in advanced melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination2009

    • Author(s)
      Nakai N, Katoh N, Germeraad WT, Kishida T, Ueda E, Takenaka H, Mazda O, Kishimoto S
    • Journal Title

      J Dermatol Sci 53(1)

      Pages: 40-47

    • Peer Reviewed
  • [Journal Article] Evaluation of survival in Japanese stage IV melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cells2008

    • Author(s)
      Nakai N, Katoh N, Kitagawa T, Ueda E, Takenaka H, Kishimoto S
    • Journal Title

      J Dermatol 35(12)

      Pages: 801-3

    • Peer Reviewed
  • [Journal Article] Pleiotrophic Functions of Epstein-Barr Virus Nuclear Antigen-1 (EBNA-1) and oriP Differentially Contribute to the Efficacy of Transfection/expression of Exogenous Gene in Mammalian Cells2008

    • Author(s)
      Kishida, T., H. Asada, K. Kubo, Y. Sato, M. Shin-Ya, J. Imanishi, K. Yoshikawa & O. Mazda
    • Journal Title

      J. Biotechnol 133 (2)

      Pages: 201-207

    • Peer Reviewed
  • [Journal Article] IL-21 induces inhibitor of differentiation 2 (Id2) and leads to complete abrogation of anaphylaxis in mice2007

    • Author(s)
      Kishida, T., Y. Hiromura, M. Shin-Ya, H. Asada, H. Kuriyama, M. Sugai, A. Shimizu, Y. Yokota, T. Hama, J. Imanishi, Y. Hisa & O. Mazda
    • Journal Title

      J. Immunol 179 (12)

      Pages: 8554-8561

    • Peer Reviewed
  • [Presentation] Double Cancer of Planter Malingnant Melanoma and Vulvar Extramammary Paget's Disease2008

    • Author(s)
      Tsuji M, Nakai N, Ueda E, Takenaka H, Katoh N, Kishimoto S
    • Organizer
      The 10th China-Japan Joint Meeting of Dermatology
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      20081030-1102

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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