2009 Fiscal Year Final Research Report
An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system
| Project/Area Number |
19592328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
KURITA Kenichi Aichi Gakuin University, 歯学部, 教授 (40133483)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Kyoko 愛知学院大学, 歯学部, 講師 (40231659)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 軟骨 / TIMP / CAM / Alginate beads / ECM / IL-1β / TGF-β / OA |
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| Research Abstract |
The results of this study suggest that TIMP-1 plays a primary role in the prevention of articular cartilage destruction in its early stage but that TIMP-3 gradually takes over this role. Also, TGF-β was shown to regulate these TIMPs and act as a suppressor of articular cartilage destruction. These results suggest that TIMP-1 and TIMP-3 are closely involved in preventing the progression of joint disorders such as OA.
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