2009 Fiscal Year Final Research Report
Development of a Hemolysis Simulator based on the Deformation Analysis of individual Red Blood Cells
| Project/Area Number |
19680024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Masanori Osaka University, 臨床医工学融合研究教育センター, 特任准教授(常勤) (20448046)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 赤血球 / 溶血 / 計算力学 / 数値流体力学 / メゾスコピック解析 |
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| Research Abstract |
Studies have been conducted for the aim of developing a hemolysis simulator based on the deformation analysis of a single red blood cell (RBC). The dynamic motion of an RBC in a flow field is calculated based on the minimum energy principle. The results for simple steady and unsteady shear flows well agreed with experimental results, corroborating the proposed RBC model. We then simulated RBC in bifurcated flows where a RBC was experimentally observed to lyse upon impingement against the apex of bifurcation. A careful investigation of the RBC deformation revealed buckling of the membrane upon collision against the wall. It was found that the area strain reached 1.81 at maximum, larger than the reported value at which a pore is formed in the lipid bilayer membrane. Those results suggested the possibility of estimating hemolysis by evaluating the area strain. In conclusion, the results address the necessity to consider deformation of RBCs for better evaluation of hemolysis and this model would be useful to build the RBC-based hemolysis simulator.
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