2022 Fiscal Year Final Research Report
Establishment of enzymomics platform for discovery of disease-related protein functions
| Project/Area Number |
19H02846
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 37030:Chemical biology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Komatsu Toru 東京大学, 大学院薬学系研究科(薬学部), 助教 (40599172)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | ケミカルバイオロジー / 創薬化学 |
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| Outline of Final Research Achievements |
In this project, we aimed to advance the concept of "enzymomics (omics of enzyme)" approach by giving it comprehensivity and sensitivity. Comprehensivity was realized by utilizing the concept of enzyme coupled assays, and the sensitivity was realized by introducing the single-molecule enzyme activity analysis platform and developing the probes suitable for them. We have accomplished them in the research period.
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| Free Research Field |
ケミカルバイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通じて，enzymomics の高度化に繋がる研究成果を，J. Am. Chem. Soc. 誌，Science Advances 誌，Cell Reports 誌などに発表し，分野の発展に努めた．特に，これを利用した疾患診断技術の重要性は世界的にも認知され，activity-based diagnosis という診断技術の意義が提唱されるに至っている．申請者らの研究は，その重要性の認知に先駆けて網羅性，感度を高めた形で実現しており，世界をリードする研究成果を継続的に発表できる基盤が整ったと言える．
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