Research on the role and function of zinc transporters in oral squamous cell carcinoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kyushu University
• Principal Investigator: Jinno Teppei 九州大学, 大学病院, 助教 (60755247)
• Co-Investigator(Kenkyū-buntansha): 川野 真太郎 九州大学, 歯学研究院, 教授 (00398067) ; 和田 尚久 九州大学, 大学病院, 教授 (60380466) ; 松原 良太 九州大学, 歯学研究院, 共同研究員 (60615798)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 亜鉛トランスポーター / ZIP6 / OSCC / IL-6 / EMT

Outline of Final Research Achievements

ZIP6 is a zinc transporter regulated by inflammatory cytokines, and ZIP6 in particular has been shown to be an essential factor for EMT, and is a molecule that is attracting attention for its relationship with cancer growth, invasion, and metastasis. ... In fact, it has been reported that breast cancer cells in which ZIP6 expression is suppressed have their proliferation ability and EMT suppressed, so it is expected that detailed analysis of the expression of these zinc transporters will progress. . In this study, we investigated the expression of zinc transporters in OSCC cells, and investigated the effects of zinc transporters on anticancer drug resistance in OSCC cells and their relationship with IL-6 signaling.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまでの研究成果および臨床経験をもとに着想したもので、抗癌剤抵抗性の分子メカニズムを解明することにより、これまでにない新規治療法を確立することを最終的な目標とする。OSCC細胞における亜鉛トランスポーターの発現や機能についてはいまだ不明な点が多く、特に抗癌剤抵抗性に与える影響について検討した報告はないため、本研究は独自の視点に立った極めて独創的な研究と言える。