The search for new AGEs inhibitors from marine bioresource

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16398
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47050:Environmental and natural pharmaceutical resources-related
• Research Institution: Showa University (2021); Showa Pharmaceutical University (2019-2020)
• Principal Investigator: Shin-ichiro Kurimoto 昭和大学, 薬学部, 講師 (70735018)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 海洋生物 / 終末糖化産物 / AGEs / 生活習慣病

Outline of Final Research Achievements

The search for new natural products inhibiting the production of advanced glycation endproducts (AGEs) from marine organisms was conducted. As a result, thirteen new compounds were isolated from marine sponges and dinoflagellates. Their structures were elucidated by the analysis of spectroscopic data. Several new compounds obtained in sufficient amount were evaluated for their AGEs production inhibitory activity. However, none of them exhibited the activity at the tested concentration. Further biological activity evaluations revealed that these compounds showed antimicrobial activity or cytotoxicity against a cancer cell line. Re-separation of new compounds for bioassay and searching for new AGEs production inhibitors from unexamined active extracts are currently in progress.

Free Research Field

天然物化学

Academic Significance and Societal Importance of the Research Achievements

タンパク質の糖化により生じるAGEsは、糖尿病合併症、アルツハイマー型認知症、非アルコール性脂肪肝炎などの様々な疾病の病態形成に関与することが報告されており、AGEs阻害作用はこれらの疾病の予防・治療に有効な新たな作用として期待されている。本研究において、海綿動物や渦鞭毛藻などから見いだした新規化合物は既存のAGEs阻害物質とは大きく異なる化学構造をもつことから、これらがAGEs阻害活性を示すことを明らかにすることができれば、AGEsが病態形成に関与する疾病の治療薬・予防薬開発のための新たなシーズとなり得る。