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2020 Fiscal Year Final Research Report

Developing a novel strategy to treat dementia through chemical genetics

Research Project

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Project/Area Number 19K22478
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionHokkaido University

Principal Investigator

Sonoshita Masahiro  北海道大学, 遺伝子病制御研究所, 教授 (80511857)

Project Period (FY) 2019-06-28 – 2021-03-31
Keywords認知症 / キナーゼ / ショウジョウバエ
Outline of Final Research Achievements

There has been a significant increase in the number of dementia patients according to the progress of an aging society. To solve this issue, we developed a novel dementia model in Drosophila expressing mutant Tau. These flies displayed lethality due to neuronal death. Through comprehensive genetic screening in these flies, we identified kinases whose mutation suppressed lethality in flies. Inhibitors against these novel therapeutic targets rescued such phenotypes, validating our strategy as a novel path to control dementia.

Free Research Field

遺伝学、創薬科学

Academic Significance and Societal Importance of the Research Achievements

近年、高齢化社会が一層進行しており、これに伴って認知症に罹患する患者数の増加が続いている。認知症の病態はいまだ不明点が多く、有効な治療標的も不明であるため、新規治療法の開発は難航している。我々は認知症の新規モデルハエの作出に成功するとともに、新規治療標的となるキナーゼを見出し、その阻害剤がこのモデルの症状を緩和できることを見出した。今後一層深刻化することが予想される認知症に対し、これらの成果は重要な研究基盤となると期待される。

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Published: 2022-01-27  

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