Comprehensive analysis of post-translational modification of herpesvirus based on big data analysis using supercomputer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22524
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 49:Pathology, infection/immunology, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授 (60292984)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: HSV / 蛋白質翻訳後修飾 / MDシミュレーション

Outline of Final Research Achievements

We have comprehensively identified post-translational modifications (PTM) of the proteins encoded by herpes simplex virus (HSV). Among the HSV proteins, PTM of the proteins responsible for HSV functional regulations were identified by molecular dynamics (MD) simulation. It was suggested that PTM is responsible reducing the motility of the functional domain of HSV proteins.

Free Research Field

ウイルス学

Academic Significance and Societal Importance of the Research Achievements

HSV生活環を司る感染特異的な翻訳後修飾は、理想的な抗HSV剤の創薬標的となりうることから、本技術基盤の創成および各HSV蛋白質の翻訳後修飾の意義の解明は重要な研究課題であると考えられる。