2020 Fiscal Year Final Research Report
Mobile genetic element TEM-1 beta-lactamase
Project/Area Number |
19K23965
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0902:General internal medicine and related fields
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Research Institution | Kyoto University |
Principal Investigator |
Noguchi Taro 京都大学, 医学研究科, 助教 (10847578)
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | 薬剤耐性大腸菌 / 水平伝播 |
Outline of Final Research Achievements |
β-lactam has a critical role in treatment of bacterial infections, β-lactamase producing bacteria has become a major public health threat worldwide. To invesitigate mechanisms underlying spread of TEM-1, the most common β-lactamase in Escherichia coli, we performed genome analysis of E. coli collected from mutliple Japansese hospitals. TEM-1 in most isolates was flanked by transposon. In one isolate, TEM-1 with transposon was found in putative plasmid strucure. The structure with high similarity was also found in isolates with different genetic phylogeny, which implies horizontal transfer of TEM-1 by larger mobile genetic element than transposon. These results will contribute to control TEM-1 producing E. coli.
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Free Research Field |
感染症内科学
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Academic Significance and Societal Importance of the Research Achievements |
細菌感染症治療の中心を担うβラクタム薬に耐性を示すβラクタマーゼ産生細菌が世界的な脅威となっている。本研究は、そのβラクタマーゼの拡散要因の解明に寄与するもので、βラクタマーゼ産生菌拡散の制御に向けた研究への発展が期待できる。
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