2020 Fiscal Year Final Research Report
The roles of M4 macrophages in Systemic Sclerosis.
Project/Area Number |
19K24004
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0904:Internal medicine of the bio-information integration and related fields
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Research Institution | Nippon Medical School |
Principal Investigator |
Iseki Yuko 日本医科大学, 医学部, 助教 (50723045)
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | 全身性強皮症 / 単球 / マクロファージ / CXCL4 |
Outline of Final Research Achievements |
Systemic scleroderma (SSc) is a collagen disease of unknown cause, with fibrosis of the skin and various organs, vascular endothelial damage, and immune disorders. It has been reported that monocytes and macrophages play an important role in the pathogenesis of SSc. Here we identified that the percentage of M4 monocytes / macrophages in peripheral blood in patients with SSc is significantly higher compared to those in healthy controls. It was suggested that CXCL-4 induced M4 monocyte/macrophage may play important roles in pathogenesis of SSc. However, the markers characteristic of M4 monocytes / macrophages have not been established, and further analysis should be necessary in the future.
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Free Research Field |
リウマチ膠原病
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Academic Significance and Societal Importance of the Research Achievements |
全身性強皮症は難治性の膠原病であり、治療法が確立されていないのが現状である。 M4単球/マクロファージが全身性強皮症の病態に関与している事が判明すれば、M4単球/マクロファージを標的とする新規治療の開発につながると考えられる。
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