Development of tissue engineering method using bioabsorbable scaffolds and new intestinal regeneration method using red LED

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24014
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0905:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: The University of Tokushima
• Principal Investigator: YOSHIKAWA Masato 徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (60737097)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 再生医療 / 短腸症候群 / 腸管延長 / 脂肪由来幹細胞

Outline of Final Research Achievements

The purpose of this study is to develop a more efficient intestinal regeneration method as a radical treatment for short bowel syndrome.
We have already created an intestinal regeneration model in rats using a silicone tube. By modifying this method to use a bioabsorbable tube instead of a silicone tube and irradiate it with a red LED, the intestinal regeneration ability is improved and reopening of the abdomen is not necessary to remove the scaffold. In this study, we investigated its usefulness for clinical application of intestinal regeneration in short bowel syndrome.
I have succeeded in creating new intestinal regeneration models using a silicone tube and a bioabsorbable PGA tube in rats. In both groups, full-thickness intestinal regeneration was obtained at 8 weeks, and nerve fibers were also confirmed. In the PGA tube group, it was completely absorbed and disappeared. However, there was no effect of extending the intestinal tract by red LED irradiation.

Free Research Field

消化器外科学、小児外科学

Academic Significance and Societal Importance of the Research Achievements

生体分解性チューブをscaffoldにした腸管再生モデルにおいて、腸管再生速度の促進および足場の除去を要さない長い再生腸管が得られた。短腸症候群患者において比較的簡単な手術手技や安価な医療資材によって自己組織による効果的な腸管の延長が可能となり、根本的治療の存在しない短腸症候群の患者にとって大きな福音となる可能性があると思われる。