2012 Fiscal Year Final Research Report
Epigenome analysis of cancer
| Project/Area Number |
20229005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NISHIKAWA Shinichi 独立行政法人理化学研究所, 幹細胞研究グループ, グループディレクター (60127115)
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| Co-Investigator(Kenkyū-buntansha) |
TARUI Hiroshi 独立行政法人理化学研究所, ゲノム資源解析ユニット, ユニットリーダー (90342815)
ITO Mitsuhiro 神戸大学, 大学院・保健学研究科, 教授 (50362794)
NISHIGORI Chikako 神戸大学, 医学(系)研究科(研究院), 教授 (50198454)
MATSUI Toshimitsu 神戸大学, 大学院・医学研究科, 准教授 (10219371)
NAGAI Ken-ichi 財団法人先端医療振興財団, 先端医療センター診療開発部, 部長 (50470208)
MIYAZAKI Yasushi 長崎大学, 医学(系)研究科(研究院), 教授 (40304943)
ITO Kiminari 財団法人先端医療振興財団, 血液再生研究グループ, グループリーダー (20301989)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 骨髄異形性症候群 / 5AZ治療 / メチローム / 白血病 |
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| Research Abstract |
The purpose of this study is to specify the effect of de-methylating agents on myelodysplastic syndrome (MDS) patients. So far, we have constructed promoter methylomes from 4 MDS patients (2 with RCMD and 2 with RAEB-2), as well as that from two healthy donors (commercial products). Samples from the two different subtypes clustered together, and it seems likely that DNA methylation analysis could serve as a useful diagnostic. We found an enormous over-representation of transcription factors within sets of identified genes differentially methylated between the two tumor types. Most other genes identified could also be considered to have regulatory functions with many genes encoding proteins involved in signal transduction, as well as a number of microRNA genes. We also looked at biological process associated with these gene sets. For most analyses we found an even more enormous over-representation of genes associated with various developmental processes, with many genes involved in nervous system development.
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[Journal Article] Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse2011
Author(s)
Ishitobi, H., A. Wakamatsu, F. Liu, T. Azami, M. Hamada, K. Matsumoto, H. Kataoka, M. Kobayashi, K. Choi, S. Nishikawa, S. Takahashi, and M. Ema
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Journal Title
Development
Volume: 138
Pages: 5357-5368
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[Journal Article] Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice2011
Author(s)
Fukushima, Y., M. Okada, H. Kataoka, M. Hirashima, Y. Yoshida, F. Mann, F. Gomi, K. Nishida, S. Nishikawa, and A. Uemura
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Journal Title
J Clin Invest
Volume: 121
Pages: 1974-1985
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