A novel targeting DDS for the treatment of autoimmune diseases and allergy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: OKU Naoto University of Shizuoka, 薬学部, 教授 (10167322)
• Co-Investigator(Kenkyū-buntansha): ASAI Tomohiro 静岡県立大学, 薬学部, 講師 (00381731) ; SHIMIZU Kosuke 静岡県立大学, 薬学部, 助教 (30423841)
• Project Period (FY): 2008 – 2010
• Keywords: ドラッグデリバリー / DDS / 逆標的化 / リポソーム / アレルギー / 花粉症

Research Abstract

Specific antigen-sensitized body has the antigen-specific immune cells, which recognize the antigen. The antigen-coupled carrier is recognized by the immune cells. When the carrier encapsulate certain drugs, these drugs are specifically delivered to the immune cells. This strategy would be useful for suppressing the activity of specific immune cells related allergy and other immune diseases.

Research Products

• [Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. (2010)
  • Author(s): Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Shuji Akai, Takayuki Ishii, Eriya Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, Hideo Tsukada, Naoto Oku
  • Journal Title: Int.J. of Pharmaceutics 392 Pages: 218-223
  • Peer Reviewed
• [Journal Article] PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明 (2009)
  • Author(s): 小出裕之、浅井知浩、畑中剣太朗、清水広介、横山昌幸、石田竜弘、際田弘志、奥直人
  • Journal Title: YAKUGAKU ZASSHI 129 Pages: 1445-1451
  • Peer Reviewed
• [Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon. (2008)
  • Author(s): Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
  • Journal Title: Int.J.Pharm 362 Pages: 197-200
  • Peer Reviewed
• [Presentation] RT-DDSを応用した新規スギ花粉治療法の開発 (2010)
  • Author(s): 横山智紀
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2010-11-29
• [Presentation] Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier. (2009)
  • Author(s): 小出裕之
  • Organizer: 4th International Liposome Society Conference
  • Place of Presentation: London, UK.
  • Year and Date: 2009-12-14
• [Presentation] PEG修飾ナノキャリアー頻回投与によるABC現象の機構解明 (2009)
  • Author(s): 小出裕之
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] ナノキャリア頻回投与時におけるABC現象の機構解明 (2008)
  • Author(s): 小出裕之
  • Organizer: 第24回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-30
• [Remarks] ホームページ等
  • URL: http://w3pharm.u-shizuoka-ken.ac.jp/~radiobio/gyouseki_MBC.html