2010 Fiscal Year Final Research Report
Genome-wide association study of sensitivity to narcotics
| Project/Area Number |
20390162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
IKEDA Kazutaka Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 副参事研究員 (60281656)
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| Co-Investigator(Renkei-kenkyūsha) |
SORA Ichiro 東北大学, 医学(系)研究科, 教授 (40322713)
NISHIZAWA Daisuke 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 研究員 (80450584)
KASAI Shinya 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 研究員 (20399471)
ARINAMI Tadao 筑波大学, 人間総合科学研究科, 教授 (10212648)
FUKUDA Kenichi 東京歯科大学, 歯学部, 准教授 (80228907)
UJIKE HIROSHI 岡山大学, 医歯(薬)学総合研究科, 臨床教授 (90213420)
HIGUCHI Susumu 独立行政法人国立病院機構(久里浜アルコール症センター臨床研究部), 久里浜アルコール症センター, 院長 (40156576)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬物依存 / 薬物感受性 |
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| Research Abstract |
To reveal the genetic mechanisms underlying individual differences in sensitivity to narcotics, we conducted genome-wide association study using 350 DNA samples of patients undergoing painful orofacial cosmetic surgery including bone dissection. We found associations between polymorphisms in the genes encoding mu-opioid receptor, G-protein activated inwardly rectifying potassium (GIRK) channel subunits, adrenalin receptors and voltage-dependent calcium channel subunits and opioid sensitivity and/or pain sensitivity. These findings will open new avenues for personalized pain treatment with opioid.
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[Journal Article] Implication of dopaminergic projection from the ventral tegmental area to the anterior cingulate cortex in mu-opioid-induced place preference.2010
Author(s)
Narita M, Matsushima Y, Niikura K, Narita M, Takagi S, Nakahara K, Kurahashi K, Abe M, Saeki M, Asato M, Imai S, Ikeda K, Kuzumaki N, Suzuki T
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Journal Title
Addict Biol 15
Pages: 434-447
Peer Reviewed
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[Presentation] 口腔外科手術後の下歯槽神経知覚障害と関連する遺伝子多型の網羅的探索2010
Author(s)
小林大輔,西澤大輔,福田謙一,大畠仁,高崎義人,笠井慎也,韓文華,長谷川準子,有波忠雄,柿澤卓,林田眞和,池田和隆
Organizer
日本人類遺伝学会第55回大会
Place of Presentation
さいたま
Year and Date
2010-10-28
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[Remarks] ホームページ等
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