2010 Fiscal Year Final Research Report
Experimental organ transplantation: Application of the drug-induced immune tolerance-
| Project/Area Number |
20390371
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TOMITA Yukihiro Kyushu University, 医学研究院, 研究員 (90180174)
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| Project Period (FY) |
2008 – 2010
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| Keywords | キメリズム / サイクロフォスファミド / 免疫寛容誘導 |
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| Research Abstract |
Cyclophosphamide (CP)-induced tolerance is a mixed chimerism-based tolerance induction protocol. Recently, we reported that invariant natural killer T (iNKT) cells were essential for the tolerance induction in this system. In this study, we evaluated the roles of the cytokines produced by iNKT cells.
iNKT cells were required in the initial phase of the induction of chimerism. Our results indicated that known major cytokines produced by iNKT cells were dispensable for the regulatory function of iNKT cells.
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