2010 Fiscal Year Final Research Report
Role of transcriptional factor Id in angiogenesis
| Project/Area Number |
20590878
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIYAMA Koichi The University of Tokyo, 大学院・医学系研究科, 助教 (80398221)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血管新生 / 転写因子 / シグナルクロストーク / ライブイメージング / コンピューター解析 |
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| Research Abstract |
The study aimed to investigate the role of helix-loop-helix (HLH) transcriptional factor Id1 in angiogenesis. Histological analysis showed that Id1 exhibited a mosaic pattern, mixed with strongly or weakly Id1-expressing ECs during ex vivo and in vivo angiogenesis. Analyses using cultured cells showed that Id1 regulated Dll4-Notch signaling pathway, and that Id1 expression appeared to oscillate periodically, suggesting a possible spatiotemporal regulation of the Notch signaling by Id1 in vascular endothelial cells. Furthermore, we have established a time-lapse imaging and computer-assisted analyzing system, which quantitatively characterizes the cell behavior in angiogenesis.
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[Journal Article] Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation.2010
Author(s)
Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H.
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Journal Title
Development 518(23)
Pages: 4702-4722
Peer Reviewed
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