2010 Fiscal Year Final Research Report
Analyze and regulation of chronic airway inflammation in bronchial asthma
| Project/Area Number |
20590899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Masahiko The University of Tokushima, 病院, 講師 (80325282)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Hirohisa 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50403754)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIOKA Yasuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70274199)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 閉塞性肺疾患 / アレルギー |
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| Research Abstract |
Chronic allergic airway inflammation induced refractory asthma. Especially transcription factor NF-kappa B plays central roll in these inflammations. We analyze inhibitory effect of IMD-0354, which specific I kappa-beta-kinase inhibitor, on bronchial hyperresponsiveness, airway inflammation and remodeling in airway. IMD-0354 reduce airway hyperresponsiveness, the production of Th2 cytokines, goblet cell hyperplasia, and bronchial smooth muscle hypertrophy. IMD-0354 had no adverse effects in this study. These results indicate the possibility of anti-asthmatic effects of this drug.
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