2010 Fiscal Year Final Research Report
The establishment of clinical implications regarding dual properties of carotid atherosclerosis in metabolic syndrome
| Project/Area Number |
20591068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
EMOTO Masanori Osaka City University, 大学院・医学研究科, 准教授 (90275248)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Katsuhito 大阪市立大学, 大学院・医学研究科, 講師 (60382040)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メタボリックシンドローム / 糖尿病 / 動脈硬化 / 超音波法 / サロゲートマーカー / インスリン抵抗性 / 人工膵臓 |
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| Research Abstract |
In metabolic syndrome including diabetes mellitus, dyslipidemia, and obesity, the morphological and functional changes of atherosclerosis of carotid artery, intima-media thickness (IMT) and stiffness parameter, were found to be differently associated with classical risk factors, novel biomarkers (fetuin-A and TRAIL), endothelial and smooth muscle dysfunction, and cardiovascular diseases. These findings indicate that simultaneous quantitative measurements of these dual properties of early atherosclerotic changes are of great importance in view of diagnosis, monitoring and treatment for atherosclerotic diseases.
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Research Products
(30 results)
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[Journal Article] Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus.2010
Author(s)
Emoto M, Mori K, Lee E, Kawano N, Yamazaki Y, Tsuchikura S, Morioka T, Koyama H, Shoji T, Inaba M, Nishizawa Y.
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Journal Title
Metabolism 59(6)
Pages: 873-878
Peer Reviewed
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[Journal Article] Fetuin-A is associated with calcified coronary artery disease.2010
Author(s)
Mori K, Ikari Y, Jono S, Emoto M, Shioi A, Koyama H, Shoji T, Ishimura E, Inaba M, Hara K, Nishizawa Y.
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Journal Title
Coron Artery Dis 21(5)
Pages: 281-285
Peer Reviewed
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[Journal Article] Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 Diabetes.2010
Author(s)
Mori K, Jono S, Emoto M, Kawagishi T, Yasumoto H, Konishi T, Furumitsu Y, Shioi A, Shoji T, Inaba M, Nishizawa Y.
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Journal Title
Angiology 61(1)
Pages: 86-91
Peer Reviewed
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[Journal Article] The combination of IMT and stiffness parameter beta is highly associated with concurrent coronary artery disease in type 2 diabetes.2009
Author(s)
Lee E, Emoto M, Teramura M, Tsuchikura S, Ueno H, Shinohara K, Morioka T, Mori K, Koyama H, Shoji T, Okuno Y, Inaba M, Nishizawa Y.
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Journal Title
J Atheroscler Thromb 16(1)
Pages: 33-39
Peer Reviewed
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[Journal Article] Glimepiride increases high-density lipoprotein cholesterol via increasing adiponectin levels in type 2 diabetes mellitus.2009
Author(s)
Araki T, Emoto M, Konishi T, Ikuno Y, Lee E, Teramura M, Motoyama K, Yokoyama H, Mori K, Koyama H, Shoji T, Nishizawa Y.
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Journal Title
Metabolism 58(2)
Pages: 143-148
Peer Reviewed
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[Journal Article] Non-oxidative glucose disposal is reduced in type 2 diabetes, but can be restored by aerobic exercise.2008
Author(s)
Yokoyama H, Mori K, Emoto M, Araki T, Teramura M, Mochizuki K, Tashiro T, Motozuka K, Inoue Y, Nishizawa Y.
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Journal Title
Diabetes Obes Metab 10(5)
Pages: 400-407
Peer Reviewed
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