2010 Fiscal Year Final Research Report
Molecular-pathological study on histological expression-mechanism of odontogenic tumors
| Project/Area Number |
20592208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TAKEDA Yasunori Iwate Medical University, 歯学部, 教授 (60137536)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 実験腫瘍学 / 病理診断学 / 分子病理学 / 歯原性腫瘍 / 上皮間葉相互作用 |
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| Research Abstract |
Tumorigenetic factors related to various histopathologic expression of odontogenic tumors were examined by immunohistochemical and molecular biologic methods. The results were as follows: the existence of epithelial-mesenchymal interaction between tumor cells of ameloblastoma and macrophages, cellular and molecular pathologic characteristics of peripheral epithelial odontogenic tumors, histopathologic characteristics of recurrent ameloblastoma, characteristics of basement membrane-related proteins in various stages of enamel matrix-like substance in calcifying epithelial odontogenic tumor, possibility of establishment of human dental epithelial cell lines expressing enamel-related proteins, influence of retinoic acid to tight junctions in odontogenic keratinocytes, etc.
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