2011 Fiscal Year Final Research Report
Functional analysis of host factors involved in antiviral defense networks in plants
| Project/Area Number |
20688002
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAKAHARA Kenji 北海道大学, 大学院・農学研究院, 助教 (90315606)
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| Project Period (FY) |
2008 – 2011
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| Keywords | PAMPs / RNAi / 自然免疫 / 植物ウイルス |
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| Research Abstract |
This study uncovered a novel mechanism of antiviral defense cooperatively acting with RNA silencing. In the defense, a calmodulin-like protein, rgs-CaM, binds to diverse viral RNA silencing suppressors and directs degradation of them by autophagy. Thus, the rgs-CaM-mediated defense seemed a host countermeasure against viral RNA silencing suppressors to reinforce antiviral RNA silencing in tobacco.
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[Journal Article] Silencing by small RNAs is linked to endosomal trafficking2009
Author(s)
Young Sik Lee, Sigal Pressman, Arlise P. Andress, Kevin Kim, Jamie L. White, Justin J. Cassidy, Xin Li1, Kim Lubell, Do Hwan Lim, Ik Sang Cho, Kenji Nakahara, Jonathan B. Preall1, Priya Bellare1, 5, Erik J. Sontheimer1 & Richard W. Carthew
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Journal Title
Nature Cell Biology
Volume: 11
Pages: 1150-1156
DOI
Peer Reviewed
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[Journal Article] A tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors
Author(s)
Kenji S. Nakahara, Chikara Masuta, SyoutaYamada, Hanako Shimura, Yukiko Kashihara, Tomoko S. Wada, Ayano Meguro, Kazunori Goto, Kazuki Tadamura, Kae Sueda, Toru Sekiguchi, Jun Shao, Noriko Itchoda, Takeshi Matsumura, Manabu Igarashi, Kimihito Ito, Richard W. Carthew, and Ichiro Uyeda
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Journal Title
Proceedings of the National Academy of Sciences USA
Volume: (印刷中)
URL
Peer Reviewed
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